AbstractAbstractInternational Journal of Pharmacology and Clinical Sciences,2013,2,1,9-13.Published:March 2013Type:Research ArticleAuthors:Karampal Singh, Suresh Singhal, and Punam Raghove Author(s) affiliations:Karampal Singh1*, Suresh Singhal2, Punam Raghove1 1Assistant Professor, 2Senior Professor, Department of Anaesthesiology, Pt. Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, India Abstract:Background: There has been a search for an ideal muscle relaxant which might provide ideal intubating conditions in ultra short duration with minimal side effects. Objective: To compare the intubating conditions and haemodynamic response one minute after rocuronium (0.6 mg/kg) administration, using three different induction techniques i.e. thiopentone, propofol and propofol with ephedrine. Materials and Methods: Seventy five adult patients were randomized into one of three groups: groups-A and B received thiopentone and propofol respectively and group -C received propofol with ephedrine. All groups received rocuronium 0.6mg/kg following administration of their respective drugs. Tracheal intubation was performed one minute later. An experienced anaesthesiologist assessed the intubating conditions. Haemodynamic parameters were recorded before induction of anaesthesia, post induction and one and three minutes after intubation. Results: Patient’s characteristics and baseline haemodynamic parameters were comparable in all three groups. Intubating conditions were significantly better in propofol-ephedrine group as compared to other two groups. Following intubation, rise in heart rate and blood pressure was more marked in propofol-ephedrine group as compared to other groups. Conclusion: Rocuronium 0.6 mg/kg provides better intubating conditions at one minute with propofol-ephedrine combination as compared to propofol alone or thiopentone. Keywords:Ephedrine, Hemodynamic, Intubating conditions, Propofol, Rocuronium, ThiopentoneView:PDF (508.5 KB) PDFClick here to download the PDF file. Images Mean age and weight of subjects emailfacebooklinkedintwittergoogle+pinterest ‹ Efficacy and Safety of Levofloxacin and Cefuroxime axetil in Acute Exacerbation of Chronic Bronchitis: A Comparative Study up Evaluation of Anti-arthritic Activity of Dazzle Ointment - A Polyherbal Formulation ›