Objective: To declare the national antidote of poisoning distribution system as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project, the national antidote of poisoning distribution system. The project drove the antidote of poisoning distribution guidelines and the international business model, pharmacy project guidelines project management institution guidelines of a new project. The initiative project is written through project management professionals and consisted of several parts, including the initial phase, the planning phase, the execution phase and the monitoring and controlling phase. Results: The antidote of poisoning distribution system with a defined vision, mission and goals was initiated. The services had various advantages with clinical and economic impacts on patients and healthcare services as illustrated in the review. The extension of the project was assured by risk management elements description. Furthermore, the monitoring and controlling of the services was demonstrated. The conversion to operation project though closing project stage was revealed in the analysis. Conclusion: The national antidote of poisoning distribution system is new initiative project and is considered as a part of the management of poisoning. There are multiple locations of antidote distribution services suggested and it is highly required in the Kingdom of Saudi Arabia.