Purpose: To explore the patient’s perception of Pharmaceutical care services; challenges and developments in Saudi Arabia. Methods: It is a 4-months cross-sectional survey of patient perception of pharmacists. The survey consisted of two-part demographic information and second part forty-nine questions divided into four domains. It included domain 1: Patient general perception of pharmacist domain 2: patients’ perception of pharmaceutical care services, domain 3: patient perception of visiting ambulatory care and domain 4: Patient’s perception of the pharmacist’s relationship and counseling. The 5-point likert response scale system was used. The questions were open and closed-ended. The survey was distributed through social media and as a 500-bed general hospital in Alhassa region, an ambulatory care pharmacy. The authors did the patients interview with electronic survey documentation. The survey was made an electronic format and it analyzed domain two about patient perception of pharmaceutical care services; challenges and developments in Saudi Arabia through the survey monkey system. Results: The total responders were 617 patients. Of those, 536 (87.7%) was Saudi and 75 (12.3%) was non-Saudi. The gender distribution 457 (74.1%) were females and 160 (25.9%) were males. The majority of patients visited the pharmacy in the past 12-months was 222 (36%) more than ten times while 122 (19.8%) attended (5-9 times). Most of the patient visited the pharmacy at evening 395 (64.6%). Most of the patients’ 481 (83.5%) spent less than 11 min with the pharmacist. The most pharmaceutical care services provided to patients were dispensing of prescribed medication 390 (70.8%), medication consultation 262 (47.5%), dispensing of non-medications, supplements 233 (42.3%) and dispensing of over the counter medications 229 (41.6%). The high scores of the pharmaceutical care services provide to the patients were in private’s hospitals (3.71) and community pharmacies (3.63). The most current experience of perception and challenges with high propriety scores were some pharmacy crowding, medication labels missed and patient privacy missed. The most future perception suggestion with high propriety and opportunity scores were published the pharmacy location through social media and implementation of adverse drug reaction reporting for patients. Conclusion: Patients’ perception is a crucial tool to improve pharmaceutical care. Monitor implementation of the patient medication education system with private places, monitoring of drug-related problems will support the future vision of patient perception and attitude towards the pharmacist.