@article {362, title = {Accounting and Financial in Pharmacy Practice: Education and Training}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {12}, year = {2023}, month = {September 2023}, pages = {101-114}, type = {Research Article}, chapter = {101}, keywords = {Accounting, Education, Financial, Pharmacy, Policy, Saudi Arabia., Training}, doi = {10.5530/ijpcs.2023.12.13}, author = {Yousef Ahmed Alomi and Ghadeer Zayed Aljumah and Nasser Rashid Alohlie and Naif Saleh Alamri and Maha Hussein Almadany and Riyadh M Alashban and Amani Abdullah Bahdailah and Abeer Hussin Almasoudi} } @article {287, title = {Dentist{\textquoteright}s Perception of Medication Safety in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {10}, year = {2021}, month = {March 2021}, pages = {41-46}, type = {Research Article}, chapter = {41}, abstract = {

Objectives: The study aims to discover the dentist{\textquoteright}s perceptions of medication safety in the Kingdom of Saudi Arabia. Methods: It is an analysis of a cross-sectional survey that reconnoitered the dentist{\textquoteright}s medication safety perceptions in Saudi Arabia. It selfreported an electronic survey of dentists, comprising dentists from internship to the consultant, dental specialties in Saudi Arabia. The survey contained respondents{\textquoteright} demographic information about dentists and perception of medication safety in dental care. Also, the perception of barriers averts off employment of the medication safety system in dental care. The 5-point Likert response scale system was employed with closed-ended questions. The data analysis of the dentist{\textquoteright}s knowledge of medication safety is finished through the survey monkey system. The statistical package of social sciences (SPSS), Jeffery{\textquoteright}s Amazing Statistics Program (JASP), and Microsoft excel sheet version 16 were used in the study. Results: The total number of responding dentists was 242, with the majority of them coming from the central region 95 (39.26\%) with statistically momentous among the areas (p\<0.05). Of those, 144 (59.75\%) were male, while 97 (40.25\%) were female, with statistically significant between them (p\<0.05). The average scores of dentist{\textquoteright}s perceptions of medication safety in dental care were 3.99; the dentist{\textquoteright}s high scores component was relaxed to ask for assistance support from colleagues or peers concerning medication safety (4.27). Medications storage with labeling is a vital element of medication safety in dental care (4.26). The average scores of perception of barriers prevent you from instigating medication safety in dental care (3.52). The high scores element was level of clinical knowledge about dental medications safety services (3.98) and lack of periodic training of dental staff dental medications safety services (3.94). The reliability test includes Cronbach alpha (0.933) and McDonald{\textquoteright}s ω (0.920). Conclusion: The dentist{\textquoteright}s perceptions of medication safety were flawless in Saudi Arabia. Periodic education and training medication safety in dental care is obligatory to improve the dental medication safety system and patient outcomes in dental care in Saudi Arabia.

}, keywords = {Dentist, Medication, Perception, Safety, Saudi Arabia}, doi = {10.5530/ijpcs.2021.10.7}, author = {Yousef Ahmed Alomi and Fouzia Abdul Karim Bukhary and Rahmah Abdulilah Alsinan} } @article {288, title = {Dentist{\textquoteright}s Practice of Medication Safety in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {10}, year = {2021}, month = {March 2021}, pages = {34-40}, type = {Research Article}, chapter = {34}, abstract = {

Objectives: The study aimed to exemplify the dentist{\textquoteright}s practice of medication safety in the Kingdom of Saudi Arabia. Methods: It examines a cross-sectional survey that deliberated the dentist{\textquoteright}s medication safety practice in Saudi Arabia. It self-reported an electronic survey of dentists, including dentists from internship to consultant, dental specialties in Saudi Arabia. The survey entailed respondents{\textquoteright} demographic information about dentists and the implemented medication safety in dental care, the medication{\textquoteright}s safety items stated in dental care, and dental medications implemented the medication{\textquoteright}s safety. The 5-point Likert response scale system was used with closedended questions. The data analysis of the dentist{\textquoteright}s knowledge of medication safety is completed through the survey monkey system. The statistical package of social sciences (SPSS), Jeffery{\textquoteright}s Amazing Statistics Program (JASP), and Microsoft excel sheet version 16 were employed in the study. Results: The total number of responding dentists was 242, with the mainstream of them coming from the central region 95 (39.26\%) with statistically noteworthy among the areas (p\<0.05). Of those, 144 (59.75\%) were male, while 97 (40.25\%) were female, with statistically significant between them (p\<0.05). The average scores of the executed items for medication safety in dental care were 3.12 with high scores element was adverse drug reactions documentation system (3.26), and the vision of medication safety in dental care was 3.23. The average scores of frequently of the medications safety items reported in dental care was 3.17 with high scores element was pregnancy and lactation altering system (3.88) and patient{\textquoteright}s education of dental medications (3.60). The highest scores of medication Safety (to authorities) the responsibility of types of healthcare professionals was a pharmacist (4.34) and dentist (4.23). The reliability test includes McDonald{\textquoteright}s ω (0.980) and Cronbach alpha (0.979). Conclusion: The dentist{\textquoteright}s practice of medication safety was inadequate in Saudi Arabia. Implementation of medication safety in dental care is obligatory to prevent dental mistakes and drug-related problems. Also, the study aimed to improve the patient safety culture among dental practices in Saudi Arabia.

}, keywords = {Care, Dentist, Medication, Practice, Safety, Saudi Arabia}, doi = {10.5530/ijpcs.2021.10.6}, author = {Yousef Ahmed Alomi and Fouzia Abdul Karim Bukhary and Rahmah Abdulilah Alsinan} } @article {284, title = {Knowledge of Medication Safety among Dentists in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {10}, year = {2021}, month = {March 2021}, pages = {28-33}, type = {Research Article}, chapter = {28}, abstract = {

Objectives: The present study aimed to affirm the dentist{\textquoteright}s knowledge of medication safety in the Kingdom of Saudi Arabia. Methods: It is an analysis of a cross-sectional survey that conferred dentists{\textquoteright} knowledge of medication safety in Saudi Arabia. Selfreported an electronic survey of dentists, comprising dentists from internship to the consultant, dental specialisms in Saudi Arabia. The survey contained respondents{\textquoteright} demographic information about dentists and knowledge information of designated medication safety elements, and the resources of knowledge of medication safety elements in dental care. The 5-point Likert response scale system was employed with closed-ended questions. The data analysis of the dentist{\textquoteright}s knowledge of medication safety is completed through the survey monkey system. The statistical package of social sciences (SPSS), Jeffery{\textquoteright}s Amazing Statistics Program (JASP), and Microsoft excel sheet (version 16) were used in the study. Results: The total number of responding dentists was 242, with the mainstream of them coming from the central region 95 (39.26\%) with statistically substantial among the areas (p\<0.05). Of those, 144 (59.75\%) were male, while 97 (40.25\%) were female, with statistically significant between them (p\<0.05). The total average scores of dentist knowledge of medication safety in dental care were 2.78 with high scores element, knowledge of the high alert medication in dental care was 3.48, consider the Medication Errors (MEs) as a sentinel event (3.25), and familiar with medications reconciliation in dental care (3.23). The most resources employed for medication safety for dental care were health practitioners [129 (54.20\%)] and scientific literature [118 (49.58\%)]. The reliability test was evaluated in McDonald{\textquoteright}s ω (0.955) and Cronbach alpha (0.955). Conclusion: The dentist{\textquoteright}s knowledge of medication safety was insufficient in the kingdom of Saudi Arabia. Targeting training and education of dental medication safety during undergraduate and postgraduates school of dentistry is highly suggested to improve patient{\textquoteright}s safety in dental care in Saudi Arabia.

}, keywords = {Dentists, Experiences, Knowledge, Medication safety, Saudi Arabia}, doi = {10.5530/ijpcs.2021.10.5}, author = {Yousef Ahmed Alomi and Fouzia Abdul Karim Bukhary and Tawfik A. M. Khoja and Rahmah Abdulilah Alsinan} } @article {313, title = {Knowledge of Pharmacists about Pharmacy Infection Control in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {10}, year = {2021}, month = {December 2021}, pages = {129-137}, type = {Research Article}, chapter = {129}, abstract = {

Objectives: In this study, we aimed to assess pharmacists{\textquoteright} knowledge about pharmacy infection control in the Kingdom of Saudi Arabia. Methods: This crosssectional survey study was conducted to assess pharmacists{\textquoteright} knowledge about pharmacy infection control in Saudi Arabia. We used a self-reported electronic survey questionnaire and distributed it to pharmacists, including dentists from interns to consultants and pharmacy specialists in Saudi Arabia. The survey collected demographic information of the responders and their knowledge regarding some of the selected pharmacy infection control elements in dental care. We also collected information regarding the resources they use to obtain knowledge of pharmacy infection control. We used 5-point Likert response scale system with close-ended questions to obtain their responses. The data were collected through the Survey Monkey system and analyzed using Statistical Package of Social Sciences (SPSS), Jeffery{\textquoteright}s Amazing Statistics Program (JASP), and Microsoft Excel (version 16) software. Results: A total of 435 pharmacists responded to the questionnaire, with one-quarter of them coming from the central region (97 (22.35\%)), and northern region (92 (21.2\%)), with non-statistically significant differences between regions (p=0.637). Of the total responders, 212 (48.96\%) were female, and 221 (51.04\%) were male responders, with non-statistically significant differences between them (p=0.665). Most of the responders were in the age group of 24{\textendash}30 years (151 (34.87\%)) and 36{\textendash}40 years (101 (23.33\%)), with statistically significant differences between them (p=0.000). The total average score of pharmacy infection control assessment for basic knowledge was 3.34, with high scores obtained for the elements knowledge of hand hygiene (3.86) and personal protective equipment (3.83). In comparison, the lowest scores were obtained for the elements knowledge of the accidental sharp devices immunization system (2.80), and the infection control pharmacist gets more salary than regular pharmacist (2.91). The total average score of knowledge of frequently used disinfection and antiseptics products at your healthcare institution (3.60) and the high scores were obtained for the elements knowledge of peroxygens (hydrogen peroxide) (4.63) and alcohol (isopropyl alcohol 70\%) (4.63). In comparison, the lowest scores were obtained for the element knowledge of phenolics (ortho-benzyl-parachlorophenol) (2.76) and the iodophors (povidone-iodine ointment 10\%) (2.99). The score for the single-test reliability analysis of McDonald{\textquoteright}s ω was 0.927, Cronbach{\textquoteright}s αwas 0.924, Gutmann{\textquoteright}s λ2 was 0.933, Gutmann{\textquoteright}s λ6 was 0.973, and Greater Lower Bound was 0.989. Conclusion: Pharmacists{\textquoteright} knowledge about pharmacy infection control was inadequate in the Kingdom of Saudi Arabia. Therefore, targeting to provide the necessary education and training for undergraduate and postgraduate students to improve patient infection control within pharmaceutical care in Saudi Arabia.

}, keywords = {Infection Control, Knowledge, Pharmacist, Pharmacy, Saudi Arabia.}, doi = {10.5530/ijpcs.2021.10.18}, author = {Yousef Ahmed Alomi and Ghudair Tashan Alanazi and Amani Abdullah Bahdailah and Hussa Mubarak Muwainea and Razan Alshehri} } @article {250, title = {Adult Standardized Concentration of Antibiotics Intravenous Infusion: New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {February 2020}, pages = {20-26}, type = {Review Article}, chapter = {20}, abstract = {

Objectives: To demonstrate the adult standardized concentration of Antibiotics intravenous infusion as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national standardized concentration of Antibiotics services. The projects formulated from the international business model, pharmacy project guidelines and project management institution guidelines of a new project. The initiative project is written through project management professionals and contained of several parts, including the initial phase, the planning phase, the execution phase, the monitoring and controlling phase. Results: The adult standardized concentration of Antibiotics intravenous infusion services with a defined vision, mission and goals. The services had various benefits including clinical and economic on patients as exemplified in the review. The continuous of the project assured by risk management model description. In addition, the monitoring and controlling of the services as declared. The transition to operation project though closing project stage was explored in the analysis. Conclusion: The adult standardized concentration of Antibiotics intravenous infusion services is a new initiative part of the intravenous admixture program. The standardized concentration of Antibiotics will lessening drug-related problems and improve patient safety at hospital practice; it is highly recommended to implement in the Kingdom of Saudi Arabia.

}, keywords = {Adult, Antibiotics, Concentration, Intravenous, Saudi Arabia, Services, Standardized}, doi = {10.5530/ijpcs.2020.9.5}, author = {Yousef Ahmed Alomi and Hani Alhamdan and Faiz Abdullah Bahadig} } @article {251, title = {Adult Standardized Concentration of Cardiovascular Medications Intravenous infusion: A New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {May 2020}, pages = {64-69}, type = {Review Article }, chapter = {64}, abstract = {

Objectives: To declare the adult standardized concentration of cardiovascular intravenous infusion as a new initiative in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national standardized concentration of cardiovascular services. The projects formulated from the international business model, pharmacy project guidelines and project management institution guidelines of a new project. The initiative project is written through project management professionals and consisted of several parts, including the initial phase, the planning phase, the execution phase, the monitoring and controlling phase. Results: The adult standardized concentration of cardiovascular medications intravenous infusion services defined as vision, mission and goals. The services had various benefits including clinical and economic on patients, the continuous of the project assured by risk management model description and the monitoring and controlling of the services as illustrated in the review. The transition to operation project though closing project stage explored in the analysis. Conclusion: The adult standardized concentration of cardiovascular intravenous infusion services is a new initiative part of the intravenous admixture program. The standardized concentration of cardiovascular will diminish healthcare professional workload and avoid economic burden on healthcare system; it is highly recommended to implement in the Kingdom of Saudi Arabia.

}, keywords = {Adult, Cardiovascular, Concentration, Intravenous, Saudi Arabia, Standardized}, doi = {10.5530/ijpcs.2020.9.12}, author = {Yousef Ahmed Alomi and Afnan Owedah Alshomrani and Faiz Abdullah. Bahadig and Hani Alhamdan} } @article {252, title = {Adult Standardized Concentration of Central Nervous System Medications Intravenous Infusion: A New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {August 2020}, pages = {103-107}, type = {Review Article}, chapter = {103}, abstract = {

Objectives: To declare the adult standardized concentration of central nervous system medications intravenous infusion as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national standardized concentration of central nervous system medications services. The projects formulated from the international business model, pharmacy project guidelines and project management institution guidelines of a new project. The initiative project is written through project management professionals and consisted of several parts, including the initial phase, the planning phase, the execution phase, the monitoring and controlling phase. Results: The adult standardized concentration of central nervous system medications intravenous infusion services defined as a vision, mission and goals. The services had various profits including clinical and economic on patients, the continuous of the project assured by risk management model description. In addition, the monitoring and controlling of the services and the transition to operation project though closing project stage explored in the analysis as illustrated in the review. Conclusion: The adult standardized concentration of central nervous system medications intravenous infusion services is a new initiative part of the intravenous admixture program. The standardized concentration of central nervous system medications maybe leads to reduction of medication errors and improve patient safety culture at healthcare organization; it is highly suggested to implement in the Kingdom of Saudi Arabia.

}, keywords = {Adult, Central nervous system medications, Concentration, Intravenous, Saudi Arabia, Standardized}, doi = {10.5530/ijpcs.2020.9.20}, author = {Yousef Ahmed Alomi and Hani Alhamdan and Faiz A Bahadig} } @article {248, title = {Adult Standardized Concentration of Chemotherapy Intravenous Infusion: New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {February 2020}, pages = {35-44}, type = {Review Article}, chapter = {35}, abstract = {

Objectives: To explore the adult standardized concentration of chemotherapy agent intravenous infusion as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national standardized concentration of chemotherapy agent services. The projects formulated from the international business model, pharmacy project guidelines and project management institution guidelines of a new project. The initiative project is written through project management professionals and contained of several parts, including the initial phase, the planning phase, the execution phase, the monitoring and controlling phase. Results: The adult standardized concentration of chemotherapy medications intravenous infusion services with a defined vision, mission and goals. The services had various benefits including clinical and economic on patients as explored in the review. The continuous of the project assured by risk management model description. In addition, the monitoring and controlling of the services as declared. The transition to operation project though closing project stage explored in the analysis. Conclusion: The adult standardized concentration of chemotherapy agent intravenous infusion services is a new initiative part of the intravenous admixture program. The standardized concentration of chemotherapy medications will reduce medication misadventures, decrease healthcare professional workload and avoid economic burden on healthcare system; it is highly recommended to implement in the Kingdom of Saudi Arabia.

}, keywords = {Adult, Chemotherapy, Concentration, Intravenous, Medications, Saudi Arabia, Standardized}, doi = {10.5530/ijpcs.2020.9.7}, author = {Yousef Ahmed Alomi and Faiz Abdullah. Bahadig and Hani Alhamdan} } @article {253, title = {Adult Standardized Concentration of Miscellaneous Medications Intravenous Infusion: A New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {November 2020}, pages = {131-136}, type = {Review Article}, chapter = {131}, abstract = {

Objectives: To establish the adult standardized concentration of miscellaneous medications intravenous infusion as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national standardized concentration of miscellaneous medications services. The projects formulated from the international business model, pharmacy project guidelines and project management institution guidelines of a new project. The initiative project is written through project management professionals and contained of several parts, including the initial phase, the planning phase, the execution phase, the monitoring and controlling phase. Results: The adult standardized concentration of miscellaneous medications intravenous infusion services defined as a vision, mission and goals. The services had various benefits including clinical and economic on patients, the continuous of the project assured by risk management model description and the monitoring and controlling of the services as explored in the review. The transition to operation project though closing project stage explored in the analysis. Conclusion: The adult standardized concentration of miscellaneous medications intravenous infusion services are a new initiative part of the intravenous admixture program. The standardized concentration of miscellaneous medications might diminution drug related problems, reduction of healthcare professional workload and avoid additional redundant cost; it is highly recommended to implement in the Kingdom of Saudi Arabia.

}, keywords = {Adult, Concentration, Intravenous, Miscellaneous medications, Saudi Arabia, Standardized}, doi = {10.5530/ijpcs.2020.9.27}, author = {Yousef Ahmed Alomi and Hani Alhamdan and Faiz A Bahadig} } @article {242, title = {Antibiotics Therapeutic Interchanges: A Narrative Reviews}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {February 2020}, pages = {14-19}, type = {Review Article }, chapter = {14}, abstract = {

Objective: To review the antibiotics therapeutic interchanges. Methods: It is an extensive search, or fifty databases included the following through the Saudi Digital Library (SDL) searching engine. It included the various type of studies (meta-analysis, randomized controlled studies and observational studies) in the English language with human study only for the update May 2017. The search in terms of therapeutic interchange, medication, therapy and type of disease or medication base on therapeutics class of anti-psychiatric. The medication list and switch from one drug to substitute based on the literature found the search that has included comparative safety, efficacy and cost of the type of medication for each disease and national or international evidence-based guidelines. Results: The total number of studies after an extensive search with a specific term search was 487 studies. Of those, there were 107 duplicated studies, and 380 studies included for future evaluation. After evaluation, there were 27 studies discussed the therapeutic interchange of antibiotics. Of those 27 studies, eight studies included for evaluation. Conclusion: Antibiotics therapeutic interchange system properly applicable implementation in practice. Further studies mandate to validate antibiotic therapeutic interchange. Antibiotic therapeutic interchange is highly recommended in the Kingdom of Saudi Arabia.

}, keywords = {Antibiotics, Drug, Literature, Review, Therapeutic interchanges, Therapy}, doi = {10.5530/ijpcs.2020.9.4}, author = {Yousef Ahmed Alomi and Faiz Abdullah Bahadig} } @article {266, title = {Anti-psychiatric Therapeutic Interchanges: A Narrative Reviews}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {May 2020}, pages = {59-63}, type = {Review Article }, chapter = {59}, abstract = {

Objective: To review the anti-psychiatric therapeutic interchanges drug therapy. Methods: It is an extensive search, or fifty databases comprised the following through the Saudi Digital Library (SDL) searching engine. It included the various types of studies (meta-analysis, randomized controlled studies and observational studies) in the English language with human study only for the update May 2017. The search in terms of therapeutic interchange, medication, therapy and type of disease or medication base on therapeutics class of anti-psychiatric. The medication list and switch from one drug to alternative based on the literature found the search that has included comparative safety, efficacy and cost of the type of medication for each disease and national or international evidence-based guidelines. Results: The total number of studies after an extensive search with a specific term search was 487 studies. Of those, there were 107 repeated studies, and 380 studies included for future assessment. After assessment, there were 20 studies discussed the therapeutic interchange of anti- Psychiatry. Of those 20 studies, three studies included for evaluation. Conclusion: Anti-psychiatric therapeutic interchange is seldom finding in the kinds of literature. Few observational studies discussed this matter. Further studies claim to standardized Anti-psychiatric therapeutic interchange in practice.

}, keywords = {Anti-psychiatric, Drug Therapy, Literature, Review, Therapeutic interchanges}, doi = {10.5530/ijpcs.2020.9.11}, author = {Yousef Ahmed Alomi and Faiz Abdullah. Bahadig} } @article {243, title = {Asthma Disorders Therapeutic Interchanges Drug : A Narrative Reviews}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {August 2020}, pages = {94-97}, type = {Review Article}, chapter = {94}, abstract = {

Objective: To analysis the anti-asthmatic medications therapeutic interchanges drug therapy. Methods: It is an extensive search, or fifty databases comprised the following through the Saudi Digital Library (SDL) searching engine. It encompassed the various types of studies (meta-analysis, randomized controlled studies and observational studies) in the English language with human study only for the update May 2017. The search in terms of therapeutic interchange, medication, therapy and type of disease or medication base on therapeutics class of Anti-psychiatric. The medication list and switch from one drug to another based on the literature found the search that has included comparative safety, efficacy and cost of the type of medication for each disease and national or international evidence-based guidelines. Results: The total number of studies after an extensive search with a specific term search was 487 studies. Of those, there were 107 duplicated studies, and 380 studies included for future assessment. After assessment, there were 14 studies about therapeutic interchange of medicines for asthma. Of those 14 studies, one study included for evaluation. Conclusion: Anti-asthmatic therapeutic interchange studies are occasionally finding in the literature. International asthma management guidelines as an alternative interchange of this matter. Further studies claim to standardized anti-asthmatic therapeutic interchange pharmacy field.

}, keywords = {Asthma, Drug, Literature, Review, Therapeutic interchanges, Therapy}, doi = {10.5530/ijpcs.2020.9.18}, author = {Yousef Ahmed Alomi and Faiz Abdullah Bahadig} } @article {241, title = {Cardiovascular Medications Therapeutic Interchanges: A Narrative Reviews}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {May 2020}, pages = {51-58}, type = {Review Article }, chapter = {51}, abstract = {

Objective: To review the cardiovascular medications therapeutic interchanges. Methods: It is an extensive search, or fifty databases included the following through the Saudi Digital Library (SDL) searching engine. It included the various types of studies (meta-analysis, randomized controlled studies and observational studies) in the English language with human study only for the update May 2017. The search in terms of therapeutic interchange, medication, therapy, type of disease or medication base on therapeutics class of anti-psychiatric. The medication list and switch from one drug to alternative based on the literature found the search that has included comparative safety, efficacy and cost of the type of medication for each disease and national or international evidence-based guidelines. Results: The total number of studies after an extensive search with a specific term search was 487 studies. Of those, there were 107 duplicated studies, and 380 studies included for future evaluation. After evaluation, there were 64 studies about therapeutic interchange of cardiovascular medications. Conclusion: The cardiovascular therapeutic interchange studies are wide-ranging and common available findings in the literature. Most of the studies have observational non-randomized. Comparative studies published in management guidelines as an alternative interchange of this matter. Cardiovascular therapeutic interchanges are highly recommended for execution in the Kingdom of Saudi Arabia.

}, keywords = {Cardiovascular, Drug, Literature, Review, Therapeutic interchanges, Therapy}, doi = {10.5530/ijpcs.2020.9.10}, author = {Yousef Ahmed Alomi and Faiz Abdullah Bahadig} } @article {244, title = {Chronic Diseases Therapeutic Interchanges Drug Therapy: A Narrative Reviews}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {August 2020}, pages = {98-102}, type = {Review Article }, chapter = {98}, abstract = {

Objective: To review the chronic diseases (gastrointestinal disorders, rheumatic arthritis etc.) therapeutic interchanges drug therapy. Methods: It is an extensive search, or fifty databases included the following through the Saudi Digital Library (SDL) searching engine. It included the various types of studies (meta-analysis, randomized controlled studies and observational studies) in the English language with human study only for the update May 2017. The search in terms of therapeutic interchange, medication, therapy and type of disease or medication based on therapeutics class of anti-psychiatric. The medication list and switch from one drug to alternative based on the literature found the search that has included comparative safety, efficacy and cost of the type of medication for each disease and national or international evidence-based guidelines. Results: The total number of studies after an extensive search with a specific term search was 487 studies. Of those, there were 107 duplicated studies, and 380 studies included for future evaluation. After evaluation, there were 19 studies about therapeutic interchange of chronic medications (Rheumatoid arthritis (RA) or Gastrointestinal disorder (GIT). Of those 19 studies, eight studies included for evaluation. Conclusion: Gastrointestinal and rheumatic arthritis medications, therapeutic interchange more practical and prevent the economic burden on healthcare systems. The implementation of therapeutic interchange of those medications is highly recommended at healthcare institutions in the Kingdom of Saudi Arabia.

}, keywords = {Chronic diseases, Gastrointestinal, Literature, Medications, Review, Rheumatic arthritis, Therapeutic interchanges}, doi = {10.5530/ijpcs.2020.9.19}, author = {Yousef Ahmed Alomi and Faiz Abdullah Bahadig} } @article {272, title = {Dermatology Medications Therapeutic Interchanges: A Narrative Reviews}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {November 2020}, pages = {124-127}, type = {Review Article }, chapter = {124}, abstract = {

Objective: To review the dermatology medications therapeutic interchanges therapy. Methods: It is an extensive search, or fifty databases comprised the following through the Saudi Digital Library (SDL) searching engine. It included the various types of studies (meta-analysis, randomized controlled studies and observational studies) in the English language with human study only for the update May 2017. The search in terms of therapeutic interchange, medication, therapy and type of disease or medication base on therapeutics class of anti-psychiatric. The medication list and switch from one drug to substitute based on the literature found the search that has included comparative safety, efficacy and cost of the type of medication for each disease and national or international evidence-based guidelines. Results: The total number of studies after an extensive search with a specific term search was 487 studies. Of those, there were 107 duplicated studies, and 380 studies included for future assessment. After assessment, 375 Records were excluded due to Non dermatology therapeutics interchange. Of the previous search, there were 5 studies that had been found discussed the dermatology medications therapeutic interchanges. Conclusion: There were few studies about medications used in skin disorder therapeutic interchange. It is better to start for generic substitutes and based on the international Therapeutic dermatology guidelines.

}, keywords = {Dermatology Medications, Initiative, Saudi Arabia, System, Therapeutic Interchange}, doi = {10.5530/ijpcs.2020.9.25}, author = {Yousef Ahmed Alomi and Faiz Abdullah. Bahadig} } @article {273, title = {ENT Medications Therapeutic Interchanges: A Narrative Review}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {November 2020}, pages = {128-130}, type = {Review Article}, chapter = {128}, abstract = {

Objective: To analysis the ENT medications therapeutic interchanges therapy. Methods: It is an extensive search, or fifty databases comprised the following through the Saudi Digital Library (SDL) searching engine. It included the various types of studies (meta-analysis, randomized controlled studies and observational studies) in the English language with human study only for the update May 2017. The search in terms of therapeutic interchange, medication, therapy and type of disease or medication base on therapeutics class of anti-psychiatric. The medication list and switch from one drug to another based on the literature found the search that has included comparative safety, efficacy and cost of the type of medication for each disease and national or international evidence-based guidelines. Results: The total number of studies after an extensive search with a specific term search was 487 studies. Of those, there were 107 duplicated studies, and 380 studies included for future assessment. After assessment, 375 Records were excluded due to non-ENT therapeutics interchange. Of the previous search, there were 5 review studies that had been found discussed the ENT medications therapeutic interchanges. Conclusion: There are no randomized controlled or observational studies about ear, nose, throat therapeutic interchange. The ENT therapeutic guidelines as evidence sources of therapeutic interchange in this subject.

}, keywords = {Ear, ENT, Literature, Nose, Review, Therapeutic interchanges, Throat}, doi = {10.5530/ijpcs.2020.9.26}, author = {Yousef Ahmed Alomi and Faiz Abdullah. Bahadig} } @article {265, title = {Mass Gathering (Hajj) Clinical Pharmacy Services: New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {May 2020}, pages = {48-50}, type = {Review Article}, chapter = {48}, abstract = {

Objective: To declare the clinical pharmacy services during the mass gathering hajj period as a new initiative in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national mass gathering pharmaceutical programs. The projects drove the mass gathering medicine guidelines and the international business model, pharmacy project guidelines project management institution guidelines of a new project. The initiative project is written through project management professionals and consisted of several parts, including the initial phase, the planning phase, the execution phase and the monitoring and controlling phase. Results: The mass gathering clinical pharmacy services with a defined vision, mission and goals. The services had multiple benefits, including clinical and economical on the healthcare system, as described in the review. The continuation of the services assured by risk management elements description. Moreover, the monitoring and controlling of the projects as illustrated. The transition to operation project, though closing project stage illustrated in the analysis. Conclusion: The clinical pharmacy services during the mass gathering hajj period is a new initiative project in the mass gathering medicine. Multiple clinical pharmacy services can be started during a mass gathering with an emphasison decrease morbidity and mortality; it is highly recommended in the Kingdom of Saudi Arabia.

}, keywords = {Clinical pharmacy, Hajj, Initiative, Mass Gathering, Saudi Arabia}, doi = {10.5530/ijpcs.2020.9.9}, author = {Yousef Ahmed Alomi and Nezar Adnan Yahya Khayat and Yasir Abdulraheem Bamagaus and Sultan Mesfer Aljumayi and Hani Mohammed Ali Jumah and Ahmad M. AlKharoby and Wael H. Motair} } @article {269, title = {Mass Gathering (Hajj) Community Pharmacies Services: New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {August 2020}, pages = {87-89}, type = {Review Article }, chapter = {87}, abstract = {

Objective: To illustrate the pharmacy indicators during the mass gathering hajj as a new initiative in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national mass gathering pharmaceutical programs. The projects drove the mass gathering medicine guidelines and the international business model, pharmacy project guidelines project management institution guidelines of a new project. The initiative project is written through project management professionals and consisted of several parts, including the initial phase, the planning phase, the execution phase and the monitoring and controlling phase. Results: The mass gathering community pharmacy services with a defined vision, mission and goals. The services had various advantages, including clinical and economic on patients and healthcare services as demonstrated in the review. The continuation of the project assured by risk management elements description. Furthermore, the monitoring and controlling of the services as illustrated. The transition to operation project, though closing project stage declared in the analysis. Conclusion: The mass gathering medication safety is a new initiative project is part of the mass gathering medicine. There are various part of medication safety services can be started during mass gathering; it is highly recommended in Saudi Arabia.

}, keywords = {Community pharmacy, Hajj, Initiative, Mass Gathering, Saudi Arabia}, doi = {10.5530/ijpcs.2020.9.16}, author = {Yousef Ahmed Alomi and Nezar Adnan Yahya Khayat and Yasir Abdulraheem Bamagaus and Sultan Mesfer Aljumayi and Hani Mohammed Ali Jumah and Ahmad M. AlKharoby and Wael H. Motair} } @article {268, title = {Mass Gathering Hajj Emergency Pharmacy: New Initiative Project in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {August 2020}, pages = {84-86}, type = {Review Article}, chapter = {84}, abstract = {

Objectives: To explore the mass gathering hajj emergency pharmacy as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national mass gathering pharmaceutical programs. The projects drove the mass gathering medicine guidelines and the international business model, pharmacy project guidelines project management institution guidelines of a new project. The initiative project is written through project management professionals and consisted of several parts, including the initial phase, the planning phase, the execution phase and the monitoring and controlling phase. Results: The mass gathering emergency pharmacy services with a defined vision, mission and goals. The services had various benefits, including clinical and economical on pilgrims, as described in the review. The continuity of the project assured by the risk management model description. Moreover, the monitoring and controlling of the services as demonstrated. The transition to operation project though closing project stage exemplified in the analysis. Conclusion: The mass gathering emergency pharmacy is a new initiative project in the mass gathering medicine. There are various emergency pharmacy services can be started during the mass gathering with clinical emergency pharmacy; it is highly suggested in Saudi Arabia.

}, keywords = {Emergency pharmacy, Hajj, Initiative, Mass Gathering, Saudi Arabia, Services}, doi = {10.5530/ijpcs.2020.9.15}, author = {Yousef Ahmed Alomi and Nezar Adnan Yahya Khayat and Yasir Abdulraheem Bamagaus and Osama Hamad Alahmadi and Majed Mohammd Alluhibi and Ahmad M. AlKharoby and Wael H. Motair} } @article {264, title = {Mass Gathering (Hajj) Medication Safety Services: New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {May 2020}, pages = {45-47}, type = {Review Article }, chapter = {45}, abstract = {

Objective: To demonstrate the mass gathering hajj medication safety as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national mass gathering pharmaceutical programs. The projects drove the mass gathering medicine guidelines and the international business model, pharmacy project guidelines project management institution guidelines of a new project. The initiative project is written through project management professionals and consisted of several parts, including the initial phase, the planning phase, the execution phase and the monitoring and controlling phase. Results: The medication safety services during the mass gathering with a defined vision, mission and goals. The services had multiple benefits, including clinical and economical on patients and healthcare services, as described in the review. The extension of the project assured by risk management elements description. Besides, the monitoring and controlling of the services as illustrated. The conversion of operation project, though closing project stage illustrated in the analysis. Conclusion: The mass gathering medication safety is a new initiative project that is part of the mass gathering medicine. There is various part of medication safety services can be started during the mass gathering; it is highly recommended in Saudi Arabia.

}, keywords = {Hajj, Initiative, Mass Gathering, Medication safety, Saudi Arabia, Services}, doi = {10.5530/ijpcs.2020.9.8}, author = {Yousef Ahmed Alomi and Nezar Adnan Yahya Khayat and Yasir Abdulraheem Bamagaus and Osama Hamad Alahmadi and Majed Mohammd Alluhibi and Ahmad M. AlKharoby and Wael H. Motair} } @article {270, title = {Mass Gathering (Hajj) Pharmacy Indicators: New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {November 2020}, pages = {114-116}, type = {Review Article}, chapter = {114}, abstract = {

Objective: To demonstrate the mass gathering hajj pharmacy indicators as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national mass gathering pharmaceutical programs. The projects drove the mass gathering medicine guidelines and the international business model, pharmacy project guidelines project management institution guidelines of a new project. The initiative project is inscribed through project management professionals and contained several parts, including the initial phase, the planning phase, the execution phase and the monitoring and controlling phase. Results: The pharmacy indicators during the mass gathering with a defined vision, mission and goals. The services had several benefits with monitoring the clinical and economic of mass gathering pharmaceutical care, as demonstrated in the review. The continuation of the project guaranteed by the risk management model description. Furthermore, the monitoring and controlling of the services as demonstrated. The transition to operation project, though closing project stage declared in the analysis. Conclusion: The mass gathering pharmacy indicators is new initiative project is part of the mass gathering medicine. There are several sections of pharmacy indicators can be initiated during mass gathering; it is highly suggested in Saudi Arabia.

}, keywords = {Hajj, Indicators, Initiative, Mass Gathering, Pharmacy, Saudi Arabia., Services}, doi = {10.5530/ijpcs.2020.9.22}, author = {Yousef Ahmed Alomi and Nezar Adnan Yahya Khayat and Yasir Abdulraheem Bamagaus and Abdulrahman Safar Alqthami and Fareed Ali Alharpi and Ahmad M. AlKharoby and Wael H. Motair} } @article {263, title = {Mass Gathering (Hajj) Pharmacy Infection Control: New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {February 2020}, pages = {5-9}, type = {Review Article }, chapter = {5}, abstract = {

Objectives: To demonstrate the pharmacy infection control services during the mass gathering Hajj period as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national mass gathering pharmaceutical programs. The projects drove the mass gathering medicine guidelines and the international business model, pharmacy project guidelines project management institution guidelines of a new project. The initiative project is written through project management professionals and consisted of several parts, including the initial phase, the planning phase, the execution phase and the monitoring and controlling phase. Results: The mass gathering pharmacy infection control services with a defined vision, mission and goals. The services had various aids, including clinical and economical on pilgrims, as illustrated in the assessment. The continuation was of the project assured by the risk management model description. Besides, the monitoring and controlling of the services as declared. The transition to operation project, though closing the project stage, explored in the analysis. Conclusion: The mass gathering pharmacy infection control services are a new initiative, part of the mass gathering medicine. There are various pharmacy transition care services can be started during the mass gathering with an emphasis on pharmacy personnel, infection control; it is highly suggested to implement in Saudi Arabia.

}, keywords = {Control, Hajj, Infection, Initiative, Mass Gathering, Pharmacy, Saudi Arabia, Services}, doi = {10.5530/ijpcs.2020.9.2}, author = {Yousef Ahmed Alomi and Lamees Essa Abdullah Hakami and Nezar Adnan Yahya Khayat and Yasir Abdulraheem Bamagaus and Taha Mohamd Rafuden Bakhsh and Nojoud Adnan Khayat and Ahmad M. AlKharoby and Wael H. Motair} } @article {262, title = {National Mass Gathering Pharmaceutical Care Program at Healthcare Institution in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {February 2020}, pages = {1-4}, type = {Review Article}, chapter = {1}, abstract = {

Objective: To explore the pharmaceutical care services during mass gathering (MG) Hajj at the healthcare organizations in Saudi Arabia (SA). Methods: It is a descriptive analysis of a newly established program at the MOH in SA called MG pharmaceutical care program during Hajj and Umra Seasons, which was analyzed within the Pharmacy Strategic Plan 2012-2020 and update the plan with new Saudi vision 2030. Results: MG pharmaceutical care program is a new program established by the healthcare organizations in the last four years, which amongst to provide pharmaceutical care services in various fields. Conclusion: The mass gathering of pharmaceutical care services is a new initiative, part of the mass gathering medicine. The program should expand after the foundation stage with performance indication monitoring and follow up. Further assessment of the new project is required to validate the clinical and economic outcomes to research the high level of quality and professionalism in the future.

}, keywords = {Healthcare, Institution, Mass Gathering, National, Pharmaceutical Care, Saudi Arabia}, doi = {10.5530/ijpcs.2020.9.1}, author = {Yousef Ahmed Alomi and Nouf Hameed AL-Muwallad and Nezar Adnan Yahya Khayat and Yasir Abdulraheem Bamagaus and Taha Mohamd Rafuden Bakhsh and Nojoud Adnan Khayat and Ahmad M. AlKharoby and Wael H. Motair} } @article {245, title = {Ophthalmic medication Therapeutic Interchanges: A Narrative Reviews}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {November 2020}, pages = {120-123}, type = {Review Article}, chapter = {120}, abstract = {

Objective: To review the ophthalmic medication therapeutic interchanges therapy. Methods: It is an extensive search, or fifty databases comprised the following through the Saudi Digital Library (SDL) searching engine. It included the various types of studies (meta-analysis, randomized controlled studies and observational studies) in the English language with human study only for the update May 2017. The search in terms of therapeutic interchange, medication, therapy and type of disease or medication base on therapeutics class of Anti-psychiatric. The medication list and switch from one drug to another based on the literature found the search that has included comparative safety, efficacy and cost of the type of medication for each disease and national or international evidence-based guidelines. Results: The total number of studies after an extensive search with a specific term search was 487 studies. Of those, there were 107 duplicated studies, and 380 studies included for future evaluation. After evaluation, there were 5 studies had been found discussed the ophthalmic medications. Conclusion: Ophthalmic medications therapeutic interchange is rare in finding studies about the topic. It recommended starting generic interchange or evidence-based ophthalmic therapeutic international guidelines.

}, keywords = {Eye, Literature, Ophthalmic, Review, Therapeutic interchanges}, doi = {10.5530/ijpcs.2020.9.24}, author = {Yousef Ahmed Alomi and Faiz Abdullah Bahadig} } @article {254, title = {Pediatrics Standardized Concentration of Antibiotics Intravenous Infusion: A New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {February 2020}, pages = {27-34}, type = {Review Article}, chapter = {27}, abstract = {

Objectives: To declare the pediatrics and neonates standardized concentration of antibiotics intravenous infusion as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national standardized concentration of antibiotics services. The projects formulated from the international business model, pharmacy project guidelines and project management institution guidelines of a new project. The initiative project is written through project management professionals and contained of several parts, including the initial phase, the planning phase, the execution phase, the monitoring and controlling phase. Results: The pediatrics and neonates standardized concentration of antibiotics intravenous infusion services defined as a vision, mission and goals. The services had various benefits including clinical and economic on patients, the continuous of the project assured by risk management model description and the monitoring and controlling of the services as explored in the review. The transition to operation project though closing project stage established in the analysis. Conclusion: The pediatrics and neonates standardized concentration of antibiotics intravenous infusion services are a new initiative part of the intravenous admixture program. The pediatrics and neonates standardized concentration of antibiotics will prevent drug related misadventures and implement of patient safety at healthcare organizations; it is highly recommended to implement in the Kingdom of Saudi Arabia.

}, keywords = {Antibiotics, Concentration, Intravenous, Neonates, Pediatrics, Saudi Arabia, Standardized}, doi = {10.5530/ijpcs.2020.9.6}, author = {Yousef Ahmed Alomi and Faiz Abdullah. Bahadig and Hani Alhamdan} } @article {255, title = {Pediatrics Standardized Concentration of Cardiovascular Intravenous Infusion Medications: A New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {May 2020}, pages = {70-75}, type = {Review Article}, chapter = {70}, abstract = {

Objectives: To explore the pediatrics and neonates standardized concentration of cardiovascular intravenous infusion as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national standardized concentration of cardiovascular intravenous infusion services. The projects formulated from the international business model, pharmacy project guidelines and project management institution guidelines of a new project. The initiative project is written through project management professionals and consisted of several parts, including the initial phase, the planning phase, the execution phase, the monitoring and controlling phase. Results: Results indicates that the pediatrics and neonates standardized concentration of cardiovascular intravenous infusion services with a defined vision, mission and goals. The services had multiple benefits including clinical and economic on patients, the continuous of the project assured by risk management model description and the monitoring and controlling of the services as explored in the review. The transition to operation project though closing project stage confirmed in the analysis. Conclusion: The pediatrics and neonates standardized concentration of cardiovascular intravenous infusion services is a new initiative as part of the intravenous admixture program. The pediatrics and neonates standardized concentration of cardiovascular might diminution the workload of healthcare, pharmacy staff and avoid additional unnecessary economic burden on healthcare system; it is highly recommended to implement in the Kingdom of Saudi Arabia.

}, keywords = {Cardiovascular, Concentration, Intravenous, Neonates, Pediatrics, Saudi Arabia, Services, Standardized}, doi = {10.5530/ijpcs.2020.9.13}, author = {Yousef Ahmed Alomi and Hani Alhamdan and Faiz Abdullah Bahadig} } @article {258, title = {Pediatrics Standardized Concentration of Central Nervous System Intravenous Infusion Medications: A New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {August 2020}, pages = {108-112}, type = {Review Article }, chapter = {108}, abstract = {

Objectives: To establish the pediatrics and neonates standardized concentration of central nervous system intravenous infusion as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national standardized concentration of central nervous system intravenous infusion services. The projects formulated from the international business model, pharmacy project guidelines and project management institution guidelines of a new project. The initiative project is written through project management professionals and consisted of several parts, including the initial phase, the planning phase, the execution phase, the monitoring and controlling phase. Results: The pediatrics and neonates standardized concentration of central nervous system intravenous infusion services with a defined vision, mission and goals. The services had multiple benefits including clinical and economic on patients, the continuous of the project confident by risk management model description and the monitoring and controlling of the services as explored in the review. The transition to operation project though closing project stage confirmed in the analysis. Conclusion: The pediatrics and neonates standardized concentration of central nervous system intravenous infusion services is new initiative as part of the intravenous admixture program. The pediatrics and neonates standardized concentration of central nervous system intravenous infusion properly reduce medication errors and improve patient safety culture system; it is highly recommended to implement in the Kingdom of Saudi Arabia.

}, keywords = {Central Nervous System, Concentration, Intravenous, Neonates, Pediatrics, Saudi Arabia, Services, Standardized}, doi = {10.5530/ijpcs.2020.9.21}, author = {Yousef Ahmed Alomi and Faiz Abdullah Bahadig and Hani Alhamdan} } @article {257, title = {Pediatrics Standardized Concentration of Chemotherapy Intravenous Infusion: A New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {May 2020}, pages = {76-83}, type = {Review Article}, chapter = {76}, abstract = {

Objectives: To discover the pediatrics and neonates standardized concentration of chemotherapy intravenous infusion as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national standardized concentration of chemotherapy intravenous infusion services. The projects formulated from the international business model, pharmacy project guidelines and project management institution guidelines of a new project. The initiative project is written through project management professionals and consisted of several parts, including the initial phase, the planning phase, the execution phase, the monitoring and controlling phase. Results: The pediatrics and neonates standardized concentration of chemotherapy intravenous infusion services with a defined vision, mission and goals. The services had various paybacks including clinical and economic on patients as discovered in the review. The continuous of the project was assured by risk management model description and the monitoring and controlling of the services as declared. The transition to operation project though closing project stage demonstrated in the analysis. Conclusion: The pediatrics and neonates standardized concentration of chemotherapy intravenous infusion services is a new initiative as part of the intravenous admixture program. The pediatrics and neonates standardized concentration of chemotherapy intravenous infusion will lessen medication errors and recover patient safety at healthcare system; it is highly recommended to implement in the Kingdom of Saudi Arabia.

}, keywords = {Concentration chemotherapy, Intravenous, Neonates, Pediatrics, Saudi Arabia, Standardized}, doi = {10.5530/ijpcs.2020.9.14}, author = {Yousef Ahmed Alomi and Faiz A Bahadig and Hani Alhamdan} } @article {259, title = {Pediatrics Standardized Concentration of Miscellaneous Mediations Intravenous Infusion: A New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {November 2020}, pages = {137-142}, type = {Review Article }, chapter = {137}, abstract = {

Objectives: To declare the pediatrics and neonates{\textquoteright} standardized concentration of miscellaneous mediations intravenous infusion as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national standardized concentration of miscellaneous mediations intravenous infusion services. The projects formulated from the international business model, pharmacy project guidelines and project management institution guidelines of a new project. The initiative project is written through project management professionals and contained of several parts, including the initial phase, the planning phase, the execution phase, the monitoring and controlling phase. Results: The pediatrics and neonates{\textquoteright} standardized concentration of miscellaneous mediations intravenous infusion services with a defined vision, mission and goals. The services had multiple benefits including clinical and economic on patients, the continuous of the project assured by risk management model description and the monitoring and controlling of the services as declared as explored in the review. The transition to operation project though closing project stage demonstrated in the analysis. Conclusion: The pediatrics and neonates{\textquoteright} standardized concentration of miscellaneous mediations intravenous infusion services is a new initiative as part of the intravenous admixture program. The pediatrics and neonates{\textquoteright} standardized concentration of miscellaneous mediations intravenous infusion might improve patient outcome and avoid added unnecessary cost; it is highly recommended to implement in the Kingdom of Saudi Arabia.

}, keywords = {Concentration, Intravenous, Miscellaneous, Neonates{\textquoteright}, Pediatrics, Saudi Arabia, Services, Standardized}, doi = {10.5530/ijpcs.2020.9.28}, author = {Yousef Ahmed Alomi and Hani Alhamdan and Faiz Abdullah Bahadig} } @article {260, title = {Pharmacist Prescribing System: A New Initiative in the Kingdom of Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {August 2020}, pages = {90-93}, type = {Review Article}, chapter = {90}, abstract = {

Objectives: To declare the pharmacist prescribing system as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national Pharmacist prescribing system services. The projects formulated from the international business model, pharmacy project guidelines and project management institution guidelines of a new project. The initiative project is written through project management professionals and contained of several parts, including the initial phase, the planning phase, the execution phase, the monitoring and controlling phase. Results: The pharmacist prescribing system services with a defined vision, mission and goals. The services had various benefits including clinical and economic on patients as illustrated in the review. The continuation of the project assured by risk management model description. In addition, the monitoring and controlling of the services as declared. The transition to operation project, though closing project stage explored in the analysis. Conclusion: The pharmacist prescribing system services is new initiative, part of the clinical pharmacy program. The Pharmacist prescribing system will reduce drug-related problems, improve clinical and economic outcomes of patients and the healthcare system and create patient{\textquoteright}s safety culture at healthcare organization; it is highly recommended to implement in Saudi Arabia.

}, keywords = {Initiative, Pharmacist, Prescribing, Saudi Arabia, Services, System}, doi = {10.5530/ijpcs.2020.9.17}, author = {Yousef Ahmed Alomi and Saleh Ibrahim ALdakheel and Faiz Abdullah Bahadig} } @article {271, title = {Pharmacy Transition Care Services during Mass Gathering Hajj in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {November 2020}, pages = {117-119}, type = {Review Article }, chapter = {117}, abstract = {

Objective: To declare the pharmacy transition care services during the mass gathering hajj period as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national mass gathering pharmaceutical programs. The projects drove the mass gathering medicine guidelines and the international business model, pharmacy project guidelines project management institution guidelines of a new project. The initiative project is written through project management professionals and consisted of several parts, including the initial phase, the planning phase, the execution phase and the monitoring and controlling phase. Results: The mass gathering pharmacy transition care services with a defined vision, mission and goals. The services had multiple benefits, including clinical and economical on pilgrims, as demonstrated in the review. The extension of the project assured by risk management elements description. In addition, the monitoring and controlling of the services as illustrated. The conversion of operation project, though closing project stage, demonstrated in the analysis. Conclusion: The pharmacy transition care services during the mass gathering is a new initiative, part of the mass gathering medicine. Various pharmacy transition care services can be started during mass gathering; it is highly recommended to implement in Saudi Arabia.

}, keywords = {Hajj, Initiative, Mass Gathering, Pharmacy, Saudi Arabia, Services, Transition Care}, doi = {10.5530/ijpcs.2020.9.23}, author = {Yousef Ahmed Alomi and Nezar Adnan Yahya Khayat and Yasir Abdulraheem Bamagaus and Naif Olaythah Alharbi and Fareed Ali Alharpi and Ahmad M. AlKharoby and Wael H. Motair} } @article {247, title = {Therapeutic Interchange: New Initiative System in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {February 2020}, pages = {10-13}, type = {Review Article}, chapter = {10}, abstract = {

Objective: To validate the therapeutic interchange system at healthcare institutions as new initiatives in the Kingdom of Saudi Arabia. Methods: It is a new initiative project drove by national therapeutic interchange system programs. The projects drove the therapeutic interchange system guidelines and the international business model, pharmacy project guidelines project management institution guidelines of a new project. The initiative project is written through project management professionals and contained of several parts, including the initial phase, the planning phase, the execution phase and the monitoring and controlling phase. Results: The therapeutic interchange services with a defined vision, mission and goals. The services had various aids, including clinical and economical, on patients and the healthcare system, as exemplified in the assessment. The continuation was of the project assured by the risk management model description. Besides, the monitoring and controlling of the services as declared. The transition to operation project, though closing the project stage, explored in the analysis. Conclusion: The therapeutic interchange system is a new initiative, part of the formulary management. There are various therapeutic interchange system classes of medications can be started though antibiotics, gastrointestinal medications and anti-psychiatric medications; it is highly recommended to implement in Saudi Arabia.

}, keywords = {Drug Therapy, Initiative, Medications, Saudi Arabia, System, Therapeutic Interchange}, doi = {10.5530/ijpcs.2020.9.3}, author = {Yousef Ahmed Alomi and Faiz Abdullah Bahadig} } @article {198, title = {Cost Analysis of Clinical Compounding in Saudi Arabia: Antibiotic Pediatrics Formulations}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {November 2019}, pages = {s7-s10}, type = {Research Article}, chapter = {s7}, abstract = {

Objectives: The aim of this study to explore the cost analysis of selected pediatrics antibiotics formularies in the Kingdom of Saudi Arabia. Methods: It is a retrospective cost analysis of pediatrics formulations at 300-beds pediatrics and maternity hospital in Riyadh city, Saudi Arabia. The pharmacy section received the specific formulation from physician then the expert pharmacist applied the international standard of clinical compounding through providing to healthcare staff over eight hours per days for five days per a week. The pediatrics formulations consisted of selected four antibiotics (Nitrofurantoin, Oseltamivir, Chloroquine and Clindamycin). The analysis of the cost included the variable expenses included personal cost, material and supply cost, Costs fixed including direct cost, non-salary cost and overhead cost. The cost was derived from the Ministry of Health information database. All cost used US dollar currency. The study analyzed the cost of anti-hypertension pediatrics formulations through the Microsoft Excel sheet version 10th. Results: The estimated average total standard cost of pediatrics formulations per hour was (53.82 USD). The average estimated cost of Nitrofurantoin per each preparation was (14.13 USD) which consisted of standard cost (0.31 USD) and the direct cost was (13.82 USD). The average estimated cost of Oseltamivir per each preparation was (16.95 USD) which consisted of standard cost (0.33 USD) and the direct cost was (16.62 USD). The average estimated cost of Chloroquine per each preparation was (6.645 USD) which consisted of standard cost (4.36 USD) and the direct cost was (6.645 USD). The average estimated cost of Clindamycin per each preparation was (14.478 USD) which consisted of standard cost (2.018 USD) and the direct cost was (12.46 USD). Conclusion: There are varieties in the cost analysis between selected pediatric formulation and manufactured ready-made products. The pharmacist should select the cheapest one among them. The cost analysis of pediatrics formulation was used for health insurance coverage and to meet the updated pharmacy strategic plan and Saudi vision 2030 in the Kingdom of Saudi Arabia.

}, keywords = {Antibiotic, Clinical, Compounding, Cost, Formulations, Ministry of Health, Pediatrics, Saudi Arabia}, doi = {10.5530/ijpcs.2019.8.37}, author = {Yousef Ahmed Alomi and Malika Alhadab and Faiz Bahadig and Mohammad Jabir Al Harbi and Mona Lubbad and Ebtesam Nazal} } @article {199, title = {Cost Analysis of Clinical Compounding in Saudi Arabia: Anticonvulsant Pediatrics Formulations}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {November 2019}, pages = {s11-s14}, type = {Research Article}, chapter = {s11}, abstract = {

Objectives: The aim of this study is to explore the cost analysis of pediatrics anticonvulsant formulations in Saudi Arabia. Methods: It is a retrospective cost analysis of pediatrics formulations at 300-beds pediatrics and maternity hospital in Riyadh city, Saudi Arabia. The pharmacy section received the specific formulation from physician then the expert pharmacist applied the international standard of clinical compounding through of providing to healthcare staff over eight hours per days for five days per a week. The pediatrics formulations consisted of selected four anticonvulsant medications. The analysis of the cost included the variable expenses included personal cost, material and supply cost, Costs fixed including direct cost, non-salary cost and overhead cost. The cost was derived from the Ministry of Health information database. All cost was used US dollar currency. The study analyzed the cost of anticonvulsant pediatrics formulations through the Microsoft Excel sheet version 10th. Results: The estimated average total standard cost of pediatrics formulations per hour was (53.82 USD. The average estimated cost of Levetiracetam per each one preparation was (53.313 USD). The total annual cost of Levetiracetam was (18,126.42 USD). The average estimated cost of Topiramate per each one preparation was (22.66 USD). The total annual cost of Topiramate was (1,087.68 USD). The average estimated cost of Rufinamide per each one preparation was (29.342 USD), while the total annual cost of Rufinamide was (293.42 USD). Conclusion: This is the first study about cost analysis of anticonvulsant pediatrics formulations in KSA and Middle East. There are some differences in the cost analysis between the pharmacy preparations and manufactured related to internal and external reasons. The pharmacist should select the cheapest one among them the preparations. The cost analysis of pediatrics formulation meets the Saudi vision 2030 strategic plan in the Kingdom of Saudi Arabia.

}, keywords = {Anticonvulsant, Clinical, Compounding, Cost, Formulations, Ministry of Health, Pediatrics, Saudi Arabia}, doi = {10.5530/ijpcs.2019.8.38}, author = {Yousef Ahmed Alomi and Malika Alhadab and Faiz A. Bahadig and Mona Lubbad and Ebtesam Nazal and Khulud Khalid Alnami} } @article {197, title = {Cost Analysis of Clinical Compounding in Saudi Arabia: Antihypertensive of Pediatric Formulations}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {November 2019}, pages = {s2-s6}, type = {Research Article}, chapter = {s2}, abstract = {

Objectives: The primary objective of this study was to explore cost analysis of pediatric formulations in Riyadh city, Saudi Arabia. Methods: This is a retrospective study of cost analysis of pediatric formulations at 300-bed pediatric and maternity hospital in Riyadh city, Saudi Arabia. The pharmacy section of this hospital receives the specific formulation from the physician. Then, the expert pharmacist applied the international standard for clinical compounding and provides services to the healthcare staff and patients over 8 hr per day for 5 days per week. The pediatric formulations consisted of but not limited to antibiotics, anti-tuberculosis (TB) medications and anti-hypertensive medications. The cost analysis included the variable expenses such as personal cost, material cost and supply cost and fixed expenses such as direct cost, non-salary cost and overhead cost. The cost was derived from the Ministry of Health information database. All costs used have been analyzed in US dollar currency. In this study, we analyzed the cost of antihypertensive medications for pediatric use through the Microsoft Excel software (version 10). Results: The estimated average total standard cost of pediatric formulations per hour was 53.82 USD and consisted of 58.58\% (31.53 USD) for personal cost, 25.14\% (13.53 USD) for overhead cost, 3.34\% (1.8 USD) for material and supply cost and 12.93\% (6.96 USD) for the non-salary cost. The average estimated cost of Propranolol, Captopril, Methyldopa, Amlodipine and Hydralazine per each preparation was (8.27 USD, 2.37 USD, 6.88 USD, 17.385 USD) and (49.44 USD), respectively. Conclusion: To the best of our knowledge, this is the first study which demonstrated the cost analysis of antihypertensive pediatric formulation in the Kingdom of Saudi Arabia. The pediatric formulations with cost analysis can involve health insurance coverage. Targeting the cost analysis of all pediatric formulation is highly recommended to fit with Saudi vision 2030 in the Kingdom of Saudi Arabia.

}, keywords = {Analysis, Antihypertensive, Clinical, Compounding, Cost, Formulations, Pediatric, Saudi Arabia}, doi = {10.5530/ijpcs.2019.8.36}, author = {Yousef Ahmed Alomi and Fatimah Fouad Al Doughan and Faiz A. Bahadig and Malika Alhadab and Mona Lubbad and Ebtesam Nazal} } @article {200, title = {Cost Analysis of Clinical Compounding in Saudi Arabia: Anti-tuberculosis Pediatrics Formulations}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {November 2019}, pages = {s15-s18}, type = {Research Article}, chapter = {s15}, abstract = {

Objectives: In this study, we explored the cost analysis of selected pediatric antituberculosis formulations available at the pharmacy of a pediatrics and maternity hospital in Riyadh city, Saudi Arabia. Methods: This is a retrospective cost analysis study of pediatric anti-tuberculosis formulations conducted at a pediatrics and maternity hospital having 300 beds in Riyadh city, Saudi Arabia. The pharmacy section of this hospital receives the specific formulation from the physician. Then the expert pharmacist provides the clinical compounding services to healthcare staff and patients over 8 hr per day for 5 days per a week. The pediatric formulations consisted of selected anti-tuberculosis medications. The cost analysis included variable expenses such as personal cost, material cost and supply cost. Fixed costs included direct cost, nonsalary cost and overhead cost. All costs were derived from the Ministry of Health information database. All costs were analyzed in terms of US dollar currency by using the Microsoft Excel software version 10. Results: The estimated average total standard cost of pediatric anti-tuberculosis formulations per hour was (53.82 USD), which included 58.58\% (31.53 USD) personal cost, 25.14\% (13.53 USD) overhead cost, 3.34\% (1.8 USD) material and supply cost and 12.93\% (6.96 USD) non-salary cost. The average estimated cost of rifampicin per preparation was (11.36 USD). The total annual cost of rifampicin was (1363.20 USD). The average estimated cost of pyrazinamide per preparation was (6.835 USD). The total annual cost of pyrazinamide was (68.35 USD). The average estimated cost of isoniazid per preparation was (8.515 USD). The total annual cost of isoniazid was (85.15 USD). Conclusion: Two anti-tuberculosis pediatric formulations (rifampicin and isoniazid) were available for various prices, whereas pyrazinamide was not available as pediatric formulation either locally or in USA and UK. The pharmacist should prepare all anti-tuberculosis pediatric formulation when needed. The cost analysis of all anti-tuberculosis pediatric formulations should be determined in order to meet health insurance and the strategies of New Saudi Vision 2030 in the Kingdom of Saudi Arabia.

}, keywords = {Anti-tuberculosis, Clinical compounding, Cost, Ministry of Health, Pediatric formulations, Saudi Arabia}, doi = {10.5530/ijpcs.2019.8.39}, author = {Yousef Ahmed Alomi and Faiz A. Bahadig and Malika Alhadab and Mona Lubbad and Ebtesam Nazal and Mayssa Ahmed Assiri} } @article {201, title = {Cost Analysis of Clinical Compounding in Saudi Arabia: Autoimmune and Gastrointestinal Pediatric Formulations}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {November 2019}, pages = {s19-s23}, type = {Research Article}, chapter = {s19}, abstract = {

Objectives: To explore the cost analysis of selected autoimmune and gastrointestinal pediatric formulations in Riyadh city, Saudi Arabia. Methods: This is a retrospective cost analysis study of autoimmune and gastrointestinal pediatric formulations at a pediatrics and maternity hospital in Riyadh city, Saudi Arabia. The extemporaneous pharmacy section regularly receive prescriptions with specific formulation from physician. The expert pharmacist applies the international standard of clinical compounding for all pediatric formulation related issue over 8 hr per days for 5 days per a week. The pediatric formulations consisted selected autoimmune and gastrointestinal medications. The cost analysis includes variable expenses such as personal cost, material cost and supply cost and fixed costs includes direct cost, non-salary cost and overhead cost. All costs were derived from the Ministry of Health information database. All costs were considered based on US dollar currency. In this study, we analyzed the cost of autoimmune and gastrointestinal pediatric formulations through the use of Microsoft Excel software version 10. Results: The estimated average total standard cost of pediatric formulations per hour was (53.82 USD). The average estimated cost of hydrocortisone per preparation was (12.896 USD). The total annual cost of hydrocortisone was (1547.52 USD). The average estimated cost of prednisolone per preparation was (4.6 USD). The average estimated cost of allopurinol per preparation was (6.99 USD) and the average estimated cost of sildenafil per preparation was (25.05 USD). The average estimated cost of omeprazole per each one preparation was (24.07 USD) and the total annual cost of omeprazole was (7221 USD). The average estimated cost of ranitidine per preparation was (5.248 USD) and the total annual cost of ranitidine was (2760.45 USD). The average estimated cost of baclofen per preparation was (21.266 USD) and the total annual cost of baclofen was (7655.76 USD). Conclusion: Based on the cost analysis, the cost of selected pediatric autoimmune and gastrointestinal pediatric formulations were higher than the ready-made products manufactured by pharmaceutical companies. The pharmacist should select the cheapest one among them. The cost analysis of pediatric formulation can be used to cover health insurance and meet the updated pharmacy strategic plan and New Saudi Vision 2030 in the Kingdom of Saudi Arabia.

}, keywords = {Autoimmune, Clinical, Compounding, Cost, Formulations, Gastrointestinal, Ministry of Health, Pediatrics, Saudi Arabia}, doi = {10.5530/ijpcs.2019.8.40}, author = {Yousef Ahmed Alomi and Malika Alhadab and Mona Lubbad and Faiz A. Bahadig and Ebtesam Nazal} } @article {204, title = {Cost Analysis of Clinical Compounding in Saudi Arabia: Excipients and Vehicles of Pediatric Formulations}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {November 2019}, pages = {s32-s35}, type = {Research Article}, chapter = {s32}, abstract = {

Objectives: To explore cost analysis of excipients of pediatric formulations in Saudi Arabia. Methods: It is a retrospective cost analysis of pediatric formulations at 300-beds pediatrics and maternity hospital in Riyadh city, Saudi Arabia. The pharmacy section received the specific formulation from physician then the expert pharmacist applied the international standard of clinical compounding through by providing to healthcare staff over eight hours per days for five days per a week. The pediatric formulations consisted selected excipients of pediatric formulations. The analysis of the cost included the variable expenses included personal cost, material and supply cost. Fixed costs including direct costs, non-salary cost and overhead cost. The cost was derived from the Ministry of Health information database. All cost was used US dollar currency. The study analyzed the cost of excipients of pediatric formulations through the Microsoft Excel sheet version 10th. Results: The estimated average total standard cost of pediatric formulations per hour was (53.82 USD and consisted of 58.58 \% (31.53 USD) for personal cost, 25.14 \% (13.53 USD) for overhead cost, 3.34\% (1.8 USD) for material and supply cost, 12.93 \% (6.96 USD) for non-salary cost. The average estimated cost of Simple Syrup per each preparation was (1.974USD). The total annual cost of simple syrup was (426.38 USD). The average estimated cost of methyl cellulose 1\% plus simple syrup per each preparation was (3.721USD). The total annual cost of methyl cellulose 1\% was (759.1USD). The average estimated cost of methyl cellulose 1\% per each preparation was (2.5 USD). The total annual cost of methyl cellulose 1\% was (584.8 USD). The average estimated cost of methyl cellulose 2\% per each preparation was (3.655 USD). The total annual cost of Methyl Cellulose 2\% (438.6 USD). Conclusion: This is the first of cost analysis of excipients of pediatric formulations in Saudi Arabia. Most of excipients of pediatric formulations products not registered in the famous countries. The hospital pharmacy updates annually all cost analysis of excipients pediatric formulations. The pharmacist should select the best and appropriate excipients for the formulations. The cost analysis project as part of updated the pharmacy strategic plan with new Saudi Vision 2030.

}, keywords = {Clinical, Compounding, Cost, Excipients, Formulations, Ministry of Health, Pediatrics, Saudi Arabia, Vehicles}, doi = {10.5530/ijpcs.2019.8.43}, author = {Yousef Ahmed Alomi and Malika Alhada and Faiz A. Bahadig and Mona Lubbad and Ebtesam Nazal} } @article {203, title = {Cost Analysis of Clinical Compounding in Saudi Arabia: Nephrology Pediatrics Formulations}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {November 2019}, pages = {s28-s31}, type = {Research Article}, chapter = {s28}, abstract = {

Objectives: To explore cost analysis of selected renal pediatric formulations in Riyadh city, Saudi Arabia. Methods: It is a retrospective cost analysis of pediatric formulations at 300-beds pediatrics and maternity hospital in Riyadh city, Saudi Arabia. The pharmacy section received the specific formulation from physician then the expert pharmacist applied the international standard of clinical compounding through by providing to healthcare staff over eight hours per days for five days per a week. The pediatric formulations consisted selected renal products. The analysis of the cost included the variable expenses included personal cost, material and supply cost. Fixed costs, including, direct costs, non-salary cost and overhead cost. The cost was derived from the Ministry of Health information database. All cost was used US dollar currency. The study analyzed the cost of Nephrology pediatrics formulations through the Microsoft Excel sheet version 10th. Results: The estimated average total standard cost of pediatric formulations per hour was (53.82 USD). The average estimated cost of Hydrochlorothiazide per each preparation was (5.204 USD) and the total annual cost of Hydrochlorothiazide was (2,071.2 USD). The average estimated cost of Acetazolamide per each preparation was (5.72 USD) the total annual cost of Acetazolamide was (366.1 USD). The average estimated cost of Spironolactone per each preparation was (2.513 USD) and the total annual cost of Spironolactone was (1,507.8 USD). The average estimated cost of Sodium citrate per each preparation was (1.23 USD) with a total annual cost of Sodium citrate was (599.01 USD). The average estimated cost of Citric Acid per each preparation was (1.136 USD) with a total annual cost of Citric Acid was (81.782 USD). Conclusion: Cost analysis of pediatrics formulation with emphasis on medications used for renal diseases is primary tool of pharmacoeconomic and health insurance. The pharmacist play role in the preparation of renal medications and cost analysis related issue. This is new study in Kingdom of Saudi Arabia and Gulf or Middle East countries with and meet the new Saudi vision 2030 in the Kingdom of Saudi Arabia.

}, keywords = {Clinical, Compounding, Cost, Formulations, Ministry of Health, Nephrology, Pediatrics, Saudi Arabia}, doi = {10.5530/ijpcs.2019.8.42}, author = {Yousef Ahmed Alomi and Malika Alhadab and Faiz A. Bahadig and Mona Lubbad and Ebtesam Nazal} } @article {202, title = {Cost Analysis of Clinical Compounding in Saudi Arabia: Oral Electrolyte Pediatrics Formulations}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {November 2019}, pages = {s24-s27}, type = {Research Article}, chapter = {s24}, abstract = {

Objectives: To explore cost analysis of selected oral electrolytes pediatrics formulations in the Kingdom Saudi Arabia. Methods: It is a retrospective cost analysis of pediatrics formulations at 300-beds pediatrics and maternity hospital in Riyadh city, Saudi Arabia. The pharmacy section received the specific formulation from physician then the expert pharmacist applied the international standard of clinical compounding through of providing to healthcare staff over eight hours per days for five days per a week. The pediatrics formulations consisted selected four selected electrolytes. The analysis of the cost was included the variable expenses like personal cost, material and supply cost. Fixed costs include direct cost, non-salary cost and overhead cost. The cost was derived from the Ministry of Health information database. All cost was used US dollar currency. This study analyzed the cost of anti-hypertension pediatrics formulations through the Microsoft Excel sheet version 10th. Results: The estimated average total standard cost of pediatrics formulations per hour was (53.82 USD). The average estimated cost of potassium chloride 10\% per each preparation was (2.053 USD) and the total annual cost of potassium Chloride 10\% was (172.452 USD). The average estimated cost of potassium chloride 7.5\% per each preparation was (1.342 USD) with the total annual cost of potassium chloride 7.5\% was (228.14 USD). The average estimated cost of sodium bicarbonate 8.4\% per each preparation was (0.7551 USD) with the total annual cost of sodium bicarbonate 8.4\% was (54.36 USD). The average estimated cost of calcium carbonate 200 mg/mL per each preparation was (5.45 USD) with the total annual cost of calcium carbonate 200mg/mL was (1,046.4 USD). The average estimated cost of sodium chloride 5.8\% per each preparation was (1.117 USD) which the total annual cost of sodium chloride 5.8\% was (167.55 USD). Conclusion: Most the electrolyte pediatrics formulations which are not available in the local or international market. Pharmacists should continue to prepare them with lower economic burden. The study was first done in KSA and meet new health strategic plan of Saudi vision 2030 in the Kingdom of Saudi Arabia.

}, keywords = {Clinical, Compounding, Cost, Electrolyte, Formulations, Ministry of Health, Pediatrics, Saudi Arabia}, doi = {10.5530/ijpcs.2019.8.41}, author = {Yousef Ahmed Alomi and Faiz A. Bahadig and Malika Alhadab and Mona Lubbad and Ebtesam Nazal} } @article {72, title = {A Study on Siddha Urinary Diagnostic Methodology Neerkkuri and Neikkuri in Adhiratha Azhutham (Hypertension)}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {6}, year = {2017}, month = {October 2017}, pages = {6-14}, type = {Original Article}, chapter = {6}, abstract = {

Background: In Siddha system of medicine, diagnosis of the disease is based on Ennvagai thervukal (Eight fold examination), in which Neerkkuri Neikkuri (Urine examination) is one among them. It is an effective and sensitive measure for the diagnosis and prognosis of diseases. Objectives: This study was conducted to establish the validity of prognostic and diagnostic patterns of Neikkuri (Oil on urine sign)in hypertension patients and to assess the association between the Neikkuri patterns with respect to pH and specific gravity of urine. Methods and Material: Urine samples of 40 diagnosed patients of hypertension aged between 30 to 60 years were collected. Ten healthy volunteers were also selected as control group for comparison. Biochemical analysis was done in the urine samples with urine reagent strip to confirm health status of the subjects. A drop of sesame oil was dropped over 50 ml of each urine sample and behaviour (shape of the oil spread, direction and spread time) was observed. Results: Half of the samples of urine of hypertension patients showed circular shape initially and then vacuolating to turn out into a sieve pattern and in remaining others at least a single vacuolation amounting to ring pattern indicative of Pitham were shown. Also, the urine of the hypertension patients were characterised by straw colour and aromatic odour, absence of froth and specific gravity 1.003-1.010.Volume of urine voided ranged from 1-1.5 lit and pH between 5.1-6.In most of the cases the dissemination dynamics of oil drop observed were of slow spreading nature which indicates good prognosis. Conclusion: It is concluded that hypertension has got mixed prognosis which may indicate the variation in the amenability of hypertension to the treatment. The study explored the veracity of the investigative procedure in diagnosis and prognosis of hypertension with Neikkuri examination.

}, keywords = {Athiratha Azhutham, Hypertension, Neerkkuri, Oil on Urine Sign, Siddha, Urine Examination}, doi = {10.5530/ijpcs.6.1.2}, author = {Sardar Hussain Fasila Banu and Padmini Parvathy and Srinivasan Venkatachalam and Murugan Ramamurthy and Selladurai Elansekaran and Gnanaraj Johnson Christian} } @article {109, title = {Comparative Analysis of Alternate Day and Daily Regimen of Atorvastatin in Dyslipidaemic South Indian Patients}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {5}, year = {2016}, month = {December 2016}, pages = {97-102}, type = {Research Article}, chapter = {97}, abstract = {

Background: Atorvastatin is the most commonly used drug for the treatment of dyslipidaemia. Long term administration of statins helps in the reduction of cardiovascular morbidity and mortality associated with dyslipidaemia. Number of studies have shown that alternate day dosing of statins is efficacious and safe alternative to daily dosing. Objectives: To compare the efficacy and tolerability of daily and alternate day regimen of Atorvastatin in the treatment of na{\"\i}ve dyslipidaemic South Indian patients. Materials and Methods: It is an open labeled, prospective, parallel, comparative interventional study. Ninety patients satisfying the inclusion criteria were randomized in to group 1 (n=45) and group 2 (n=45) and received atorvastatin 10 mg daily and alternate days respectively for 3 months. Pretreatment and post treatment anthropometric measurements, biochemical and lipid parameters were recorded. Patients were followed at fortnightly intervals for 3 months to check the patient compliance and adherence to treatment. Data were analyzed by suitable statistical methods. Results: There was a statistically significant reduction of total cholesterol, triglycerides, LDL, VLDL and increase of HDL cholesterol in both groups. Post treatment between group comparison shows a significantly higher reduction of LDL in group 1 than group 2 patients. All other lipid parameters were significantly similar between the groups at 12 weeks follow-up. Daily and alternate day treatment were well tolerated by the patients of both the group and there was no untoward incident during the study period. Conclusion: Alternate day administration of atorvastatin causes a beneficial alternation of lipid parameters which helps in reducing the cost and adverse effects.

}, keywords = {Adverse events, Alternate day, Atherosclerosis, Atorvastatin, Hyperlipidaemia}, doi = {10.5530/ijpcs.5.4.1}, author = {Shanmugasundaram Rajamani and Maharani Balagurumoorthy} } @article {99, title = {Dose Dependent Amitriptyline Induced Sexual Dysfunction in a Migraine Patient}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {5}, year = {2016}, month = {June 2016}, pages = {62-64}, type = {Case Report}, chapter = {62}, abstract = {

Amitriptyline is a tricyclic antidepressant. It is one of the preferred first linedrug for prophylactic treatment of migraine. Here we report a case of amitriptyline induced sexual dysfunction in a 40 year old male patient who was diagnosed with Migraine without aura.

}, keywords = {Amitriptyline, Migraine, Sexual dysfunction}, doi = {10.5530/ijpcs.5.2.5}, author = {Kavitha BB and Nischal Reddy and Shashank Ballur} } @article {95, title = {Muscle Relaxant Property of 1(4-carboxy phenyl)-4,4,6-trimethyl-1H, 4H pyrimidine-2 thiol (a Pyrimidine Derivative) in Ex vivo Smooth and Skeletal Muscle Preparations}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {5 }, year = {2016}, month = {June 2016}, pages = {49-54}, type = {Research Articles}, chapter = {49}, abstract = {

Background: Pyrimidine and its derivatives demonstrate a wide range of biological and pharmacological activities. Objective: To study the smooth muscle and skeletal muscle relaxant activity of a pyrimidine derivative 1 (4-carboxy phenyl)-4,4,6-trimethyl-1H,4H pyrimidine- 2 thiol (4CPTP), the chemical structure of which is similar to phenobarbitone. Material and Methods: Spasmolytic activity of 4CPTP was studied using rabbit ileum and guinea pig ileum preparation. Skeletal muscle relaxant activity was assessed on frog rectus abdominis preparation. Mean height of contractions with graded doses of phenobarbitone and 4CPTP along with mean inhibition of contractions were calculated. Statistical analysis was done using chi square test. Results: The test compound produced dose dependent decrease in acetylcholine and barium chloride induced contractions of rabbit ileum, histamine induced contractions of guinea pig intestine and acetyl choline induced contractions of frog rectus abdominis. Conclusion: 4 CPTP possesses spasmolytic and neuromuscular blocking activity in our ex vivo studies.

}, keywords = {Neuromuscular blocker, Phenobarbitone, Pyrimidines, Spasmolytic}, doi = {10.5530/ijpcs.5.2.3}, author = {Prem Kumar Verma and Garima Bhutani and Seema Rani and Rahul Saini} } @article {104, title = {Prescription Trend of Topical Corticosteroids in Outpatient of Dermatology in a Tertiary Care Hospital in Tumakuru, Karnataka}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {5}, year = {2016}, month = {September 2016}, pages = {77-82}, type = {Original Article}, chapter = {77}, abstract = {

Background: Skin diseases amounts for a large fraction of patients attending the outpatient of dermatology and topical corticosteroids (TCS) are being commonly prescribed, the data related to drug usage patterns of TCS in skin conditions are particularly lacking. Hence it is vital to study the drug prescribing patterns of TCS in skin diseases. Objective: To study the demographic details and drug prescription pattern of TCS in patients with skin diseases. Materials and Methods: A cross-sectional study conducted in the Dermatology Department, Sri Siddhartha Medical College, over a period of 2 months. The patients with skin diseases who were prescribed TCS were included. The data was collected by direct observation in a specially designed proforma containing relevant detail such as demography, skin conditions and drug used. The data were analyzed as counts and percentages. Result: Majority of the patients were under the age of less than 20 years (38\%) followed by those between the age of 21 years to 40 years (36\%). .Female patients (61\%) were more and majority were from rural areas (69\%). Clobetasol propionate (46\%), mometasone furoate (15\%) and betamethasone dipropionate (12\%) were the commonly prescribed TCS. Fixed dose combinations (FDC) of TCS were commonly with fusidic acid, gentamicin and salicylic acid. Average drug per prescription was 2.09. None of the prescriptions used generic names. Conclusion: Prescription pattern provides critical feedback to prescribing physician by focusing on rationalizing drug therapy. FDC of TCS with gentamicin, salicylic acid and fusidic acids are rational and approved by CDSCO.

}, keywords = {Dermatology, Prescribing pattern, Rational, Skin disease, Topical corticosteroids}, doi = {10.5530/ijpcs.5.3.3}, author = {Purushotham K and Eesha BR} } @article {113, title = {Cost, Benefit and Risks Associated with in-Campus and off-Campus Accommodations of Medical Students: A cross-Sectional Study}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {4}, year = {2015}, month = {Sept 2015}, pages = {58-62}, type = {Original Article}, chapter = {58}, abstract = {

Background: Students{\textquoteright} accommodation might influence their growth, behaviour and study performance. There is no clarity yet about safety issues, trends in substance abuse and on effect of type of accommodations on students{\textquoteright} academic performance. Objectives: To compare students{\textquoteright} perceptions regarding in campus and off campus accommodations with respect to cost, benefit and risks associated with them and also to investigate whether type of accommodation affect medical students{\textquoteright} academic performance. Materials and Methods: In this cross sectional study, the data was collected using newly designed validated questionnaires from students who had stayed in campus accommodation (n=100) and students who had stayed in off campus accommodation (n=100). Data was analyzed using SPSS version 16. The group wise comparison was made using Mann-Whitney test. A p value of \< 0.05 was considered as statistically significant. Results: The difference in the direct cost related to in campus and off campus accommodation was INR 43, 800/month with in-campus accommodation exceeding over off campus accommodation. Off-campus accommodation was perceived as more comfortable than in-campus accommodation, promoting collaborative learning and alcohol and substance abuse (p\<0.05) compared to in-campus accommodation. In addition, students who stayed in the campus performed significantly better academically than those who stayed outside the campus. Conclusion: The outside hostel accommodation is favorable to students in terms of direct cost and benefits. However, risks, including alcohol and substance abuse must be considered and appropriate precautions should be taken and counseling must be provided to students to avoid these risks.

}, keywords = {Academic Performance, Accommodation, Benefits, Cost, Medical Students}, doi = {10.5530/ijpcs.4.3.5}, author = {Vasudha Devi and Sabrina Najiha Binti Mohamad Ashari and Syahirah Binti Abd Rashid and Muhammad Azim Bin NurAdlan and Mohamed Mazlan Bin Mohamed Musadiq} } @article {110, title = {Effect of Kungiliya Vennai and Kalchunna Thailam on Excision Wound Healing in Albino Wistar Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {4}, year = {2015}, month = {Sept 2015}, pages = {52-57}, type = {Original Article}, chapter = {52}, abstract = {

Background: Kungiliya vennai and Kalchunna thailam are the two indigenous herbal formulation being used for healing of wounds in siddha medicine. Objectives: The objective of our study was to evaluate the wound healing property of topical application of kungiliya vennai (KV) and kalchunna thailam (KT) on excision wound in Sprague Dawley rats. Methods: Four groups of eight Sprague dawley female rats in each group were used for the study. Under anesthesia, excision wound of 300mm2 size was created using scissors. Group 1 served as control with no drugs applied. Group 2, 3 and 4 were applied with mupirocin, KV and KT respectively daily until wound was completely healed. Parameters observed were \% wound contraction rate and epithelialization period. Biopsy of wound for histology was taken on day 12 as well as the healed wound was taken after the wound was healed. Results were analyzed by one-way analysis of variance (ANOVA) followed by Tukey{\textquoteright}s test by keeping p\<0.05 as statistically significant. Results: Kalchunna thailam has increased wound contraction rate only during initial days, but not statistically significant. Kungiliya vennai treatment has increased vascularity with presence of tissue eosinophils when compared to control rats. There was a regeneration of adnexal skin structures in the Kungiliya vennai treated rats, which is not seen in other groups. The epithelialization period was significantly (p\<0.001) hastened in Group 3 (15.83 days) and 4 (15.17 days) compared to control group (21.33 days). Conclusion: The topical application of kungiliya vennai and kalchunna thailam promoted wound healing in rats. Kungiliya vennai has the additional property of regenerating adnexal structures such as hair follicles, sweat glands and sebaceous glands.

}, keywords = {Calcium, Kungiliya Vennai, Shorea Robusta, Siddha Medicine, Wound}, doi = {10.5530/ijpcs.4.3.4}, author = {Vishal Bhat and Arul Amuthan and Barizah Binti Mohamed Rosli and Nur Amirah Binti Khairuddin and Fatin Shahira Binti Md. Isa} } @article {130, title = {Impact of Severity of Poly Pharmacy on Medication Adherence in Patients with type II Diabetes Mellitus}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {4}, year = {2015}, month = {Dec 2015}, pages = {94-97}, type = {Research Article}, chapter = {94}, abstract = {

Background: Diabetes mellitus is a complex chronic disease and people with diabetes estimated to reach 552 million by 2030 worldwide. World Health Organization stated that only 50\% of patients diagnosed with a chronic illness were fully compliant with their treatment regime. Objectives: To test the hypothesis that adherence decreases with increase in number of medications prescribed in patients with type II diabetes mellitus. Materials and methods: It was a comparative cross sectional study conducted in the department of medicine, medical college, Kozhikode. Patients visiting in the outpatient department of general medicine who satisfy the inclusion criteria were enrolled into the study. Patient medication adherence was measured by medication adherence questionnaire. Results analyzed using student{\textquoteright}s t test. Results: A total of 218 type II diabetic patients enrolled in this 6 months study in which minor poly pharmacy accounts for 18 patients, and the remaining were major poly pharmacy regime. The average number of drugs prescribed was 4.71 {\textpm} 2.12. The mean value of medication adherence score is more in major poly pharmacy group (3.48) when compared with minor poly pharmacy group (1.96). Higher the value of medication adherence score lower is the value of medication adherence of the patient. Conclusion: Polypharmacy continues to be a significant issue and little research has been conducted regarding the relationship between medication adherence and poly pharmacy. Medication adherence is affected by certain factors other than the number of drugs prescribed.

}, keywords = {Compliance, Diabetes Mellitus, Medication Adherence, Patients, Polypharmacy}, doi = {10.5530/ijpcs.4.4.5}, author = {Manju Cheenkallel Sreenivasan and Rinisha Razak and Athira Balakrishnan and Chandni Radhakrishnan} } @article {206, title = {Learning Habits of Undergraduate Medical Students in Pharmacology}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {4}, year = {2015}, month = {September 2015}, pages = {63-67}, type = {Original Article}, chapter = {63}, abstract = {

Background: Learning pharmacology may be challenging to medical students as drug information is expanding and students are required to adopt suitable study habits to remember pharmacological aspects to develop higher cognitive skills for better academic performance. Objective: To compare the learning habits of students of various levels of academic performances in pharmacology. Methods and Material: Study was cross sectional in which students{\textquoteright} learning habits and examination scores in pharmacology were collected in a questionnaire. The questionnaire had Likert type items (1: never{\textendash}5: every time) related to learning habits of students that could influence academic performance in pharmacology. It was distributed to 2nd year MBBS students (n=243) after the two assessments in pharmacology. Based on the \% of marks obtained in previous assessments, students were categoriesed into 5 groups (1=\<50, 2=50-59, 3=60-69, 4=70-79, 5=80-100). Statistical analysis used: The categorical variables were described as median and interquartile range. Learning habits of students of various level of academic performances were compared using non parametric tests. A p value of \<0.05 was considered as significant. Results: Group 1 less frequently revised the topics more than two times compared to the group 2 (p=0.015) and 5 (p=0.002). Compared to groups 1, 2 and 3, group 5 had started the preparation \>3 days before the scheduled pharmacology class test (p\<0.05). Compared to failed students, students who passed had revised topics more than 2 times and had set the target score of \>60\% and did not momorise the topics by mere byhearting. Conclusion: Reinforcement in the form of revisions, goal setting and developing deeper understanding of concepts have emerged as major determinants of students{\textquoteright} performance in examination in pharmacology. Hence, students should be made aware of these aspects to improve the quality of studies.

}, keywords = {Academic Performance, Learning Habits, Medical, Pharmacology, Students}, doi = {10.5530/ijpcs.4.3.6}, author = {Vasudha Devi and Zulhashime bin Zulkifli and Abdul Hadi bin Abd Rahman and Nurul Wahida Amalin binti Razali and Nur Atiqah binti Md Salehuddin} } @article {94, title = {A Study on Adverse Drug Reactions to first line Antitubercular Drugs in DOTS Therapy}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {4}, year = {2015}, month = {March 2015}, pages = {7-11}, type = {Research Article}, chapter = {7}, abstract = {

Background: Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis, is the second leading infectious cause of death in the world. The objective was to study the demographic details of the tuberculosis patients experiencing adverse drug reactions (ADRs) and to identify the frequency of adverse drug reactions. Materials and Methods: : It was a prospective observational study conducted in pulmonology department of Institute of Chest Disease, Govt. Medical College, Kozhikode, Kerala, India. All the TB patients admitted at the directly observed treatment, short course (DOTS) Center at Medical College Hospital were enrolled and were monitored for ADRs. The causality and severity of the reactions were determined using Naranjo algorithm and Hartwig question-naire, respectively. Results: A total of 511 tuberculosis patients who were on DOTS therapy were enrolled for the study. Out of 511 pa-tients, 93 patients (18.20\%) developed adverse drug reactions. The higher numbers of ADRs were observed in males (68.81\%) and the remaining (31.18\%) was observed in female. Diabetes mellitus (41.02\%) was the most common comorbidity. Most of the ADR occurred in the intensive phase (85.71\%) of treatment. It was observed that pulmonary TB (55.18\%) was more common than extra pulmonary TB. Majority of adverse drug reactions were gastrointestinal (GI) problems (38.09\%). The most serious ADR was hepatitis. Isoniazid was the major drug which caused 34.40\% of adverse drug reactions. Conclusion: About 17.02\% people developed different type of ADRs during the study period. As a pharmacist we have the liability to support the patients during the period of antitubercular treatment. These ADR may steer the patient to make a judgment for stopping the medications and finally the occurrence of drug resistance and an amplified healthcare cost. If a proper educational system is implemented, most of the patients may report their ADR and thereby we can improve the patient adherence and therapeutic outcome.

}, keywords = {Adverse drug reactions, Ethambutol, Isoniazid, Pyrazinamide, Rifampicin, Tuberculosis}, author = {Athira B and Manju CS and Jyothi E} } @article {126, title = {Towards Standardization{\textendash}A New Protocol for Oil drop test (Neikuri) in Healthy Subjects}, journal = {International Journal of Pharmacology and Clinical Sciences |}, volume = {4}, year = {2015}, month = {Dec 2015}, pages = {83-89}, type = {Research Article}, chapter = {83}, abstract = {

Background: Oil drop test (Neikuri), a method of urine examination used in Siddha Medicine, an Indian system of medicine. In this test, patient urine is collected in a vessel, over which a drop of sesame oil is placed and the behavior of the oil drop on the urine surface is noted. However, due to lack of a standardized protocol for this test and advancement of modern diagnostic facilities, the utility value of this test has decreased to a greater extent. Objectives: To develop a new protocol for oil drop test in healthy subjects, so that it can be used as a standard reference to compare with other pathological conditions. Methods and Material: Urine samples of 12 healthy volunteers aged between 18 to 25 years were collected. Biochemical analysis was done in the urine samples with urine reagent strip to confirm health status of the subjects. 12 μl of sesame oil was dropped over 30 ml of each urine sample and behavior (shape of the oil spread, direction and spread time) was observed. Results: Majority of the samples showed circular shape and the most appropriate time to record it after 15 min of the test procedure. Conclusion: This test protocol can be taken as a standard technique for Oil drop test. However, further studies must be done in larger population so that it can be used as a non invasive and cost effective diagnostic/prognostic tool.

}, keywords = {Neikuri, Oil Drop Test, Oil Spread Direction and Time, Oil Spread Shape, Siddha Diagnostic Technique}, doi = {10.5530/ijpcs.4.4.3}, author = {Ahamed Basha Abdul Bari and Prince Johnson Samuel and Mathangi Damal Chandrasekar and Ramnath Shyamala and Siva Shankar Rangasamy} } @article {142, title = {Cerebroprotein Hydrolysate in Treatment of Vascular Dementia - a Case Report}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {3}, year = {2014}, month = {December 2014}, pages = {75-78}, type = {Case Report}, chapter = {75}, abstract = {

Vascular dementia (VD) is a dementia due to vascular factors and is one of common causes of dementia. Neurotrophic factors and anticholinesterases are useful in the management of disorders such as dementia or stroke. A new phar-macological agent called cerebroprotein hydrolysate has been used in the management of dementia with promising results. Here we present a case report where cerebroprotein hydrolysate showed promising improvement in the man-agement of vascular dementia.

}, keywords = {Cerebroprotein hydrolysate, Dementia, Vascular, Vascular dementia}, author = {Mosam Phirke and Anup Bharati and Avinash De Sousa and Nilesh Shah and Sushma Sonavane} } @article {131, title = {Gastroprotective Activity of Asystasia gangetica Stem Aqueous Extract Against Pylorus Ligated Gastric Ulcer in Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {3}, year = {2014}, month = {September 2014}, pages = {53-60}, type = {Research Article}, chapter = {53}, abstract = {

Background: Asystasia gangetica, a medicinal plant commonly known as Maithal Kadi available in Udupi district in India. It is used as a fresh juice to treat gastric ulcers, rheumatism, inflammation, swelling by the folklore practitioners. The present studies were aimed to investigate the antiulcer activity of aqueous extract of Asystasia gangetica stem to provide scientific validation for its folklore use. Materials and Methods: Healthy Wistar albino rats were divided into three different groups of six rats each. The rats were pre-treated with group specific drugs. Group I assigned as control, group II received the standard drug omepra-zole 20 mg/kg, group III received aqueous extract of stem of the plant Asystasia gangetica 400 mg/kg once daily for seven consecutive days. On seventh day, one hour after drug administration, the gastric ulcer was induced by ligation of the pyloric part of the rat{\textquoteright}s stomach. This was followed by the macroscopic examination of the stomach, quantifica-tion of gastric juice, total and free acidity, peptic activity and histological examination of stomach tissue were performed. The test extract were subjected for preliminary phytochemical analysis as per standard methodology. Results: The test drug treated group showed that there is a significant reduction in the total acidity and marked reduction in ulcer index, the volume of gastric juice and the effect was comparable with that of omeprazole. Histologi-cal examination revealed a normal cytoarchitecture with reduced gastric lesions in group III compared to group I. Conclusion: The present finding suggests that Asystasia gangetica promotes ulcer protection as ascertained by the comparative decreases in total acidity, gastric lesions and peptic activity.

}, keywords = {Asystasia gangetica, Gastro protection, Leukocyte, Omeprazole, Pylorus ligation, Ulcer index}, author = {Lalith Kumar and Ravi M and Shridhara Bairy and Chaithra Hebbar and Ravi Shankar B} } @article {156, title = {Effect of Flunarizine on Blood Glucose Levels in Normal Albino Rats Through Oral Glucose Tolerance Test}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {2}, year = {2013}, month = {March 2013}, pages = {19-24}, type = {Research Article}, chapter = {19}, abstract = {

Background: Flunarizine is commonly used for migraine prophylaxis. It is a calcium channel blocker which blocks the L-type, T-type and N-type of calcium channels of pancreatic beta cells and other cells. It is believed to cause alterations in blood glucose levels secondary to its effect on calcium channel dependent insulin secretion. Objective: To evaluate the effect of flunarizine on blood glucose levels in normal albino rats through oral glucose tolerance test (OGTT) Materials and Methods: Flunarizine and distilled water were given orally for 5 days to the test (T) and control (C) groups of 6 normal albino rats respectively (N = 6). OGTT was conducted on both the groups on the 5th day and blood glucose levels were analyzed at 0, 60 and 150 minutes. Data was analyzed with one way ANOVA and independent samples t -test. Results: Flunarizine caused hyperglycemia at all durations of the OGTT with a maximum difference of 26\% at 0 hour. The extent of worsening was maximum at 60 - 0 minute interval in both the instances i.e. test group value compared with control (T-C) and control values compared with itself (C-C). The comparison of extent of hyperglycemia revealed that T-C showed 17\% (47mg/dl) more hyperglycemia than the C-C (40 mg/dl). Conclusion: Flunarizine has hyperglycemic effects in normal albino rats when given for 5 consecutive days orally even at the dose used for prophylaxis of migraine in human beings. A word of caution is thus advised when using flunarizine in impaired glucose tolerance or diabetic subjects.

}, keywords = {Blood glucose level, Flunarizine, Hyperglycemic, Oral glucose tolerance test}, author = {Suresha RN and Ashwini V and Pragathi B and Kalabharathi HL and Satish AM and Pushpa VH} } @article {168, title = {Evaluation of Chemical Composition of Vaalai Rasa Chendooram: A Gold Based Herbomineral Siddha Drug}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {2}, year = {2013}, month = {September 2013}, pages = {61-66}, type = {Research Article}, chapter = {61}, abstract = {

Background: Vaalai rasa chendooram is a Siddha herbo-mineral drug used in the treatment of several diseases such as cancer, AIDS and chronic skin diseases. Literature survey revealed that scientific study was lacking for this drug. The present study was aimed at the characterization of the physico{\textendash} chemical traits of vaalai rasa chendooram. Materials and Methods: Vaalai rasa chendooram was prepared as per Agathiyar siddhar method. The ingredients were sulphur, mercury, gold, alum, potassium nitrate and Aloe vera. The prepared drug was analyzed for chemical properties using Fourier Transform Infra-Red (FTIR), Zeta potential and Differential Scanning Calorimetry and Thermogravimetric Analysis (DSC-TGA). Results: The heavy metals were absent except mercury (0.05ppm), which is below the acceptable limit. Gold (12.91\%) is the major inorganic constituent presented with other heat stable organic compounds such as flavonoids, alkaloids, glycosides, serpentines, tannin and lignin. The particle size was 846.5nm. Conclusion: Vaalai rasa chendooram is a heat stable gold-organics complex formulation. Future studies will be focused on the isolation of each organic compounds, evaluation of their pharmacological role and toxicology profile.

}, keywords = {Ayurveda, Basma, Gold, Metals, Siddha, Traditional Medicine}, author = {S. Shajahan and V. Brundha} } @article {180, title = {Experimental Evaluation of Analgesic and Anti-inflammatory Potential of Leaves of Antidesma Menasu on Wistar Albino Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {2}, year = {2013}, month = {December 2013}, pages = {105-112}, type = {Research Article}, chapter = {105}, abstract = {

Background: Antidesma menasu is a folk plant of Euphorbiacae occurring in and around Udupi district in India. It is effectively used in folklore medicine for the management of arthritis, inflammatory bowel disorder and low backache. The present study aimed to evaluate the anti-inflammatory and analgesic activity of the plant in Wistar albino rats. Aqueous extract of leaves of A. menasu were evaluated for possible analgesic and anti-inflammatory activities in Wistar albino rats. Materials and Methods:Eddy{\textquoteright}s hot plate test and radiant heat test were used for investigation of analgesic effect. Effect of extract on the acute inflammation was investigated on Carrageenan induced paw oedema, and chronic inflammation was investigated on cotton pellet induced granuloma tissue formation test. The test extract was subjected for preliminary phytochemical examination as per standard methodology. Results: The test drug found to inhibit the carrageenan induced paw oedema significantly (p ˂ 0.05) and there was moderate increase in the latency period in the analgesic test. The results suggest that the test group has high signifi-cant anti-inflammatory potential and there is moderate analgesic activity. The histopathological examination of adrenal cortex, spleen and thymus showed a normal cytoarchitecture comparable with that of normal control group. The preliminary phytochemical screening of the aqueous extract of the plant A. menasu revealed the presence of flovanoids, saponins, steroids and phenols. Conclusion: The data obtained supports the traditional folklore therapeutic claim about its anti-inflammatory and anal-gesic activity. Further scientific investigation is required to establish its analgesic and anti-inflammatory property in other experimental models and clinical settings.

}, keywords = {Antidesma menasu, Arthritis, Carrageenan, Chronic inflammation, Flavonoids}, author = {Arun Prabhakar Sithara and Ravi M and Suma Mallya and Sudhakara and Sridhar Bairy and Srikanth P and Ravishankar} } @article {186, title = {A Novel Treatment for Type2 Diabetes Mellitus: Canagliflozin}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {2}, year = {2013}, month = {December 2013}, pages = {129-134}, type = {New Drug Information}, chapter = {129}, abstract = {

Sodium glucose co-transporter type 2 (SGLT2) inhibitors, as a new class for treatment of Type 2 diabetes mellitus, offer a novel mechanism of action, and are very effective in bringing the blood sugar levels down, either alone or in combination with other oral hypoglycaemic agents, with minimal side effects. Among the several drugs in this group, which are in various stages of clinical trials, canagliflozin has been recently approved by USFDA for use in type 2 dia-betes mellitus, either alone or in combination with other oral hypoglycaemic agents and insulin.

}, keywords = {Blood glucose, Canagliflozin, SGLT2 inhibitors}, author = {Sangeeta Bhanwra and Kaza Ahluwalia} } @article {170, title = {Wound Healing Property of Topical Application of Ethanolic Extract of Michelia champaca Flowers in Diabetic Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {2}, year = {2013}, month = {September 2013}, pages = {67-74}, type = {Research Article}, chapter = {67}, abstract = {

Background: The plant Michelia champaca (MC) is widely used in the treatment of inflammation, constipation, dysmenorrhea, ulcers, wounds, fever and cough. The objective of the study was to evaluate the wound healing property of topical application of ethanolic extract of MC flowers in streptozotocin induced diabetes in rats. Materials and Methods: Wound healing activity was assessed by incision and excision wound models. Five groups of 10 rats each were used for each of incision and excision wound model. Group I rats, non-diabetic control and group II rats diabetic control, were anointed topically with ointment base. The diabetic rats in test groups III, IV and V were anointed with topical MC extract ointment of 2.5\%, 5\% and 10\% respectively. Parameters observed were breaking strength of incision wound and wound contraction, epithelialization, hydroxyproline content of excision wound respec-tively. Results were analyzed by one-way analysis of variance (ANOVA), followed by Tukey{\textquoteright}s post hoc test. Results: Breaking strength, rate of wound contraction and hydroxyproline content were significantly increased and period of epithelialization was significantly reduced in Group IV and V rats respectively. Conclusion: The topical application of ethanolic extract of Michelia champaca promotes wound healing in diabetic rats. Hence further study in humans is suggested.

}, keywords = {Diabetic Rats, Excision wound, Hydroxyproline, Incision wound}, author = {Amoolya Gowda and Venkatesh Shanbhag and Smita Shenoy and Eesha Rao Bangalore} } @article {174, title = {Areca Catechu: Effect of Topical Ethanolic Extract on Burn Wound Healing in Albino Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {1}, year = {2012}, month = {Sept 2012}, pages = {74-78}, type = {Research Article}, chapter = {74}, abstract = {

Background:\ Areca nut (Areca catechu\ Linn.) is commonly used for skin ulcers in Indian traditional medicine. Areca nut oil is prepared and is applied topically for burn wound healing. However, scientific study has not been conducted so far. Hence, this study was aimed to evaluate burn wound healing activity of Areca catechu.\ Objective:\ To evaluate the burn wound healing property of Areca catechu kernel in normal as well as dexamethasone treated rats.\ Materials and Methods:\ Ethanolic extract of Areca catechu kernel was prepared and an ointment was made with 2\% of this extract. Burn wound was induced by standard procedure. Rats with burn wound model received either vehicle, standard drug or test drug. Two other groups were injected with dexamethasone to delay the wound healing process. The dexamethasone treated groups received either vehicle or test drug topically. Wound contraction rate and period of epithelialization were measured. The collected data were subjected to statistical analysis.\ Results:\ The wound contraction rate was significantly increased in Areca catechu treated group in all the days compared to control. Period of epithelialization was faster in the drug treated group than control group. The dexamethasone treated group showed a significant delay in wound healing process when compared to control. Test drug showed a significant reversal in wound contraction rate and epithelialization period in dexamethasone suppressed burn wound healing model.\ Conclusion:\ This study has shown the wound healing property of Areca catechu. Further study is required to know the compounds responsible for its wound healing property and to understand the mechanism of action.

}, keywords = {Areca Catechu, Ayurveda, Burn Wound, Epithelialization, Siddha, Wound Contraction}, author = {Deepak Kumar Verma and Masuram Bharat and Deepak Nayak and Tara Shanbhag and Venkatesh Shanbhag and Ravindra Singh Rajput} } @article {189, title = {Case of Fosphenytoin Induced Acute Cerebellar Dysfunction and Pituitary Bleed Causing Central Diabetes Insipidus in a Case of AML M2 during Allogenic Hematopoietic Stem Cell Transplant}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {1}, year = {2012}, month = {Dec 2012}, pages = {111-114}, type = {Case Report}, chapter = {111}, abstract = {

Neuroprotectors such as phenytoin, fosphenytoin, clonazepam or levetiracetam are often used prior conditioning regimen to prevent seizures caused due to busulfan, during bone marrow transplant. Fosphenytoin and levetiracetam are used instead of phenytoin as they are readily soluble and do not need a vehicle such as polyethylene glycol or ethanol which increases risk of tissue and cardio toxicity. We report a case of acute toxicity in the form of cerebral bleed during intravenous administration of fosphenytoin and its subsequent management in patient undergoing busulfan treatment prior to allogenic transplant.

}, keywords = {Bone Marrow Transplantation, Busulfan, Conditioning Regimen, Fosphenytoin, Levetiracetam, Neuroprotector, Phenytoin}, author = {Eriat Govind and Radheshyam Naik and Srinivas BJ and Intezar Mehdi} } @article {159, title = {Hepatoprotective Activity of Plectranthus Amnoinicus Against Paracetamol Induced Hepatotoxicity in Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {1}, year = {2012}, month = {June 2012}, pages = {32-38}, type = {Research Article}, chapter = {32}, abstract = {

Background:Plectranthus amboinicus, belonging to the genus Plectranthus, is widely used for medicinal purposes. Its leaves have been used traditionally as a heatoprotective.\ Objectives:\ The present study was aimed at evaluating the heapatotective activity of ethanolic extract of Plectranthus amboinicus against paracetamol induced heapatotoxicity in rats.\ Materials and Methos:\ Sic groups wistar rats were used in the study. The two control groups received gum acacia and paracetamol orally respectively. The three test groups were treated orally with paracetamol followed by 300, 600 and 900 mg/kg of ethanolic extract of pletranthus amboinicus respectively. The sixth group (standard hepatoprotective) received paracetamol followed by N-aceltylcysteine 100 mg/kg orally. The hepatoprotective activity was evaluated by estimating serum alanine aminotransferase, asparatate aminotransferase, alkaline phosphatase, tissue malondialdehyde levels and by histopathological analysis of the liver tissue. Results were analysed by one-way ANOVA followed by Dunnett{\textquoteright}s multiple comparison test.\ Results:\ Plectranthus amboinicus in doses of 600 mg/kg and 900 mg/kg siginificantly (p\<0.05) altered paracetamol induced changes in the serum and tissue enzyme levels to near normal values. It also improved the liver histopathology profile.\ Conclusion:\ The results of the study indicate that the ethanolic extract of Plectranthus amboinicus, possesses hepathoprotective activity against paracetamol induced hepatotoxicity in rats.

}, keywords = {Hepatoprotective, N-acetylcysteine, Paracetamol, Plectranthus Amboinicus}, author = {Smita Shenoy and Hemanth Kumar and Thashma and Veena Nayak and Krishnananda Prabhu and Priya Pai and Indu Warrier and Somayaji and Venu Madhav and KL Bairy and Anoop Kishore} } @article {187, title = {Knowledge and Awareness of Food and Drug Interactions (FDI): a Survey Among Health Care Professionals}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {1}, year = {2012}, month = {Dec 2012}, pages = {105}, type = {Research Article}, chapter = {97}, abstract = {

Background:\ Most of the food and drug interactions (FDI) remain unnoticed and under reported due to either lack of proper history, follow up or unawareness. Certain foods and specific nutrients in foods, may affect the overall bioa-vailability, pharmacokinetics, pharmacodynamics and therapeutic efficacy of medications. FDI occur due to extension of drug action or due to interaction between the drug and herbal medicines as well as dietary supplements and food products.\ Objectives:\ To evaluate the knowledge, attitude and awareness regarding the common FDI among the doctors in their day to day practice.\ Materials and Methods:\ Survey included randomly selected 200 doctors divided into 3 groups [65 Professors, 83 Post Graduates (PGs) and 52 Interns] from JSS Tertiary care hospital, Mysore, India. Assessment was through FDI Questionnaire which consisted of 32 questions (included dichotomous, multiple choice and open ended ques-tions). The differences between groups were compared using one-way ANOVA followed by Bonferroni{\textquoteright}s post-hoc test. The level of significance was set at p \< 0.05.\ Results:\ The mean scores (mean {\textpm} SD) on the overall test were 26 {\textpm} 4.08, 22.89 {\textpm} 3.72, 21.35 {\textpm} 4.2 for professors, PGs and interns respectively, with 31 being a perfect score. Professors had good knowledge about FDI compared to others (p \< 0.001). Only 33\% participants have noticed FDI during their practice. A majority of doctors had heard, felt necessary to report and update their knowledge about FDI along with adequate patient counseling.\ Conclusion:\ The study showed professors had better expertise compared to others. Intensive FDI training and integration of knowledge among healthcare professionals, especially in the younger health care professionals, is a requisite.

}, keywords = {Adverse drug reactions, Drug interactions, Food and Drug Interactions, Questionnaire}, author = {Jyoti M. Benni and Jayanthi MK and Basavaraj R and Tubaki and Renuka M} } @article {188, title = {Rationality of Prophylactic Antibiotic use in Genitourinary Surgery in a Tertiary care Hospital}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {1}, year = {2012}, month = {Dec 2012}, pages = {106-110}, type = {Short Communication}, chapter = {106}, abstract = {

Antimicrobial prophylaxis is the periprocedural systemic administration of an antibiotic, used to reduce the risk of postprocedural local and systemic infections. The present retrospective study was done in 100 patients who had undergone elective genitourinary surgery in a tertiary care hospital to investigate the rationality of prophylactic use of antibiotics in genitourinary surgery according to the American Urological Association recommendations 2011. All patients undergoing genitourinary surgery had received antibiotics. Injectable antibiotic was administered within 1 hr before surgery in 95\% cases and 1-2 hrs before surgery in 5\% cases. Preoperatively single antibiotic was used in 92\%, two in 7\% and three in 1\% cases whereas postoperatively single antibiotic was used in 91\%, two in 7\% and three in 2\% cases. Most commonly administered antibiotic group preoperatively as well as postoperatively was a second generation cephalosporin, cefuroxime along with a beta lactamase inhibitor, sulbactam (90\% cases) followed by the combination of cefuroxime and an aminoglycoside, amikacin (4\% preoperatively and 5\% cases postoperatively). The number and group of antibiotic used preoperatively and postoperatively were quite identical. The average duration of antibiotic use was 3-10 days. The prophylactic use of antimicrobials in genitourinary surgeries in this hospital was rational with respect to time of administration and choice of antibiotic group. However, the duration of antimicrobial use was highly irrational which must be controlled to prevent the emergence of resistance strains and decrease the adverse effects and cost of health care to the patient.

}, keywords = {Antimicrobial, Genitourinary, Prophylactic, Rational}, author = {Rakesh Kumar and Jagminer Kaur Bajaj and Sukhbir Singh and Megha Sood} } @article {171, title = {Undergraduate Medical Srtudent{\textquoteright}s Perceptions Regarding Personal Drug Selection Exercise}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {1}, year = {2012}, month = {June 2012}, pages = {61-67}, type = {Research Article}, chapter = {61}, abstract = {

Background:\ Right drug for the right patient in the right dose for the right duration is the aim of rational prescribing. The foundation for rational prescribing can be laid if prescribing doctors are sensitized to this concept during undergraduate studies. The knowledge of personal drug (P-drug) selection process is an important step towards rational prescribing.\ Objectives:\ This study was done to analyse tje student{\textquoteright}s opinions and the difficulties they faced in the process of P-drug selection. Materials and Methods: In first phase of this study, fifth sesmester students of MBBS course were taught the process of selecting a P-drug in pharmacology practical classes. In seconf phase. students were given questionnaire to put forth their views on selection process of P-drug. The qunatitative data was expressed as median and interquartile range (IQR).\ Results:\ Majority of the students were in favor of introducing the process of selection of P-drug in udergraduate pharmacology curriculum [4 (4-5), scale 1-5]. The students were of the opinion that such exercise will given in-depth knowledge of various groups used and highlight the intragroup differences. Student{\textquoteright}s also opined that P-drug knowledge of various groups of durgs used and highlight the intragroup differences. Student{\textquoteright}s also opined that P-drug exercise also enable them to remember various aspects of the drugs for long period. Students also felt that the P-drug selection process will help them to understand hoe drug selection been for the treatment of various disease conditions.\ Conculsion:\ P-drug selection exercise helps students to understand the differences between various drugs used for the treatment of one disease condition. This may serve as a strong foundation for developing rational prescribing skills.

}, keywords = {P-drug, Pharmacology, Prescription Writing, Undergraduate Curriculum}, author = {Lalit Mohan and Bharti Chogtu and Shalini Adiga and K.L Bairy and Anoop Kishore} }