@article {210, title = {Emergency Medications Order for Adults: Standardized Concentration System in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {December 2019}, pages = {204-205}, type = {Review Article }, chapter = {204}, abstract = {

The general administration of pharmaceutical care released several publications related to the administration of intravenous medications, which mention about the concentration of intravenous medications for adults, pediatrics and neonatal patients. The publications also include several emergency medications with their concentrations. This new initiative was started in order to guide physicians to select the primary emergency medications in intravenous drip administration. The medications were selected based on common evidence-based standardized concentration for adults. This project required to control high-alert medications and prevent drug-related errors. The list of medications may be covered as computerized physician order entry and this project may be implemented as pharmacy project management.

}, keywords = {Adults, Emergency, Medications, Saudi Arabia, Standardized Concentration}, doi = {10.5530/ijpcs.2019.8.44}, author = {Yousef Ahmed Alomi and Manal Mansour Al Nemari and Fatimah Al-Doughan and Yasir Ahmed Ibrahim and Hussam Saad Almalki and Nouf Alaza and Malika Alshamari} } @article {209, title = {Emergency Medications Order for Neonates and Pediatrics: A Standardized Concentration System in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {December 2019}, pages = {206-207}, type = {Review Article}, chapter = {206}, abstract = {

The national pediatric pharmacy program was founded in 2014. It is a part of the pharmacy strategic plan. This program has implemented several projects including preparation and administration of intravenous medication to neonates and pediatric patients. The complementary new initiatives program is the neonates and pediatrics standardized concentration of emergency medications with an emphasis on medications used to treat critically ill patients and in emergency department. This new project has physician order form with selected dilutions, concentrations and route of administration. The form may be converted to a computerized order form. The new initiatives of the project may be implemented through project management tools. The project prevents drug-related problem and decrease economic burden on healthcare system for neonates and pediatrics hospitals in the Kingdom of Saudi Arabia.

}, keywords = {Concentration, Emergency, Medications, Neonates, Pediatrics, Saudi Arabia, Standardized}, doi = {10.5530/ijpcs.2019.8.45}, author = {Yousef Ahmed Alomi and Fatimah Al-Doughan and Yasir Ahmed Ibrahim and Hussam Saad Almalki and Nouf Alaza and Malika Alshamari} } @article {211, title = {Neonates and Pediatrics Electrolyte Replacement Therapy Order: New Initiative and Implementation System in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {December 2019}, pages = {211-212}, type = {Review Article}, chapter = {211}, abstract = {

The national medications safety program founded in 2013 at the Ministry of Health hospitals and primary care centers in the Kingdom of Saudi Arabia. The program focused on adults, pediatrics and neonatal populations. The program was part of the pharmacy strategic plan. The electrolyte replacement therapy preparation and administration for neonates and pediatrics published and distributed as required of the medication safety program. The new initiatives as complementary project was a standardized concentration of electrolyte replacement therapy for neonates and pediatrics implemented at specific hospitals of the Ministry of health. The new project as regular physician{\textquoteright}s order form and coveted to computerized physician order entry. The new project prevents neonates and pediatrics medication errors of electrolyte replacement therapy. The project is a new initiative at Ministry of Health hospitals in the Kingdom of Saudi, Gulf and Middle East countries.

}, keywords = {Electrolyte, Ministry of Health, Neonates, Pediatrics, Saudi Arabia, Standardized Concentration}, doi = {10.5530/ijpcs.2019.8.47}, author = {Yousef Ahmed Alomi and Fatimah Al-Doughan and Yasir Ahmed Ibrahim and Hussam Saad Almalki and Nouf Alaza and Malika Alshamari} } @article {52, title = {Pharmacist{\textquoteright}s Awareness and Knowledge of Reporting Adverse Drug Reactions in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {January 2019}, pages = {60-65}, type = {Research Article}, chapter = {60}, abstract = {

Objectives: Pharmacovigilance is considered a useful tool in detecting, assessing, understanding and preventing Adverse drug reactions (ADRs) to ensure the safety of medications and protect consumers from ADRs. Consequently, the progression and expansion of pharmacovigilance is urgent for safe and effective clinical practice; therefore, in this study, we aimed to compare the awareness and knowledge of the community and hospital pharmacists toward reporting ADRs in different regions of Saudi Arabia. Methods: This cross-sectional study was conducted from January 2016 to March 2016 in Saudi Arabia. A validated and structured questionnaire was distributed by hand or via Internet to 263 hospital and community pharmacists. The questionnaire collected pharmacists{\textquoteright} demographic information and pharmacists{\textquoteright} understanding and knowledge of the pharmacovigilance system and reporting of ADRs. Results: A total of 263 pharmacists responded to the questionnaire with 208 (79.09\%) pharmacists from hospital pharmacy sites and 55 (20.91\%) pharmacists from community pharmacy responding to the questionnaire. There is a significant difference in the pharmacovigilance concept (p\<0.05) between the hospital and community pharmacists. Most community pharmacists were unfamiliar with the existence of a pharmacovigilance center in Saudi Arabia. Furthermore, community pharmacists were unaware of where they could get an ADR reporting form, but hospital pharmacists were aware of this (p\<0.05). Conclusion: The results of this study demonstrated that pharmacists who work at hospitals among different regions in Saudi Arabia had a higher awareness of the pharmacovigilance system than that of community pharmacists who worked at the community pharmacy.

}, keywords = {Adverse drug reactions, Awareness, Knowledge, Pharmacists, Pharmacovigilance, Saudi Arabia}, doi = {10.5530/ijpcs.2019.8.11}, author = {Fatimah Fouad Al Doughan and Yousef Ahmed Alomi and Mais Hasan Iflaifel} } @article {55, title = {Pharmacist{\textquoteright}s Perception of Pharmacovigilance and Reporting of Adverse Drug Reactions in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {February 2019}, pages = {73-78}, type = {Original Article}, chapter = {73}, abstract = {

Background: Pharmacists{\textquoteright} perception toward their role in reporting of Adverse Drug Reactions (ADRs) and their understanding of the importance of reporting ADRs are essential keys to be assessed and studied in order to determine the factors that may predispose to underreporting of ADRs in Saudi Arabia. Therefore, in this study, we aimed to asses and compare the perception of community and hospital pharmacists toward reporting of ADRs in different regions of Saudi Arabia. Method: A structured, validated questionnaire was used to conduct a cross-sectional study. A total of 263 pharmacists were enrolled. The questionnaire included the demographic data of the pharmacists and 11 questions to measure pharmacists{\textquoteright} perceptions of ADRs reporting of reporting ADRs. All statistical analysis done by using Statistical Package for the Social Sciences (SPSS) version 21 and Survey Monkey system. Result: the result shows that community and hospital pharmacists strongly agree about that reporting of ADRs allow to measure the incidence of ADRs 29 (55.77\%), 121 (58.45) and to identify previously unrecognized ADRs 30 (57.69\%), 116 (56.59\%) and enable safe drugs to be identified 39 (70.91\%), 129 (62.32\%), respectively with no significant difference (p\>0.05). Besides, both hospital pharmacists 116 (55.77\%) and community pharmacists 31 (60.78\%) strongly agree about their important role in the pharmacovigilance system. However, only 67 (32.52\%) of hospital pharmacists strongly agreed about the physician{\textquoteright}s responsibility in reporting ADRs compared to community pharmacists 29 (52.73\%) with a significant difference between groups (p\<0.05). However, 37 (17.87\%) of hospital pharmacists were uncertain about drug companies{\textquoteright} role in pharmacovigilance system with a significant difference between community pharmacists with (p\<0.05). Conclusion: The result of this study demonstrated that both community and hospital pharmacists among Saudi Arabia had a very goods of perception about the importance of ADRs reporting and their role in reporting ADRs.

}, keywords = {Adverse drug reactions, Community, Hospital, Perception, Pharmacist, Pharmacovigilance, Saudi Arabia}, doi = {10.5530/ijpcs.2019.8.13}, author = {Fatima Fouad Al Doughan and Yousef Ahmed Alomi and Mais Hasan Iflaifel} } @article {56, title = {Pharmacist{\textquoteright}s Practice of Reporting of Adverse Drug Reactions in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {February 2019}, pages = {86-93}, type = {Research Article}, chapter = {86}, abstract = {

Objectives: To assess and compare the practice of reporting Adverse Drug Reactions (ADRs) and related factors between community and hospital pharmacists in Saudi Arabia. Methods: This is a cross-sectional study. We used a structured, validated questionnaire to collect the data. A total of 263 pharmacists participated in the survey. The questionnaire captures demographic data of the participants and had 26 questions related to the practice of reporting ADRs and factors that encourage and discourage pharmacists from reporting ADRs. Results: Community pharmacists did not know the location of the ADR form, but hospital pharmacists did know about it, which was significantly different (P\<0.05). Despite the increased awareness of ADR form among the hospital pharmacists{\textquoteright}, the overall reporting rate was found to be meager among both the group of pharmacists. We found that several reasons led to the low reporting rate of ADR, for example, community pharmacists were unaware of how to report ADR and they considered that the ADR is too trivial to be reported compared to hospital pharmacists (P\<0.05). in addition, community pharmacists were not know whom to report the ADRs compared to the hospital pharmacists, which was significantly different (P\<0.05). Conclusion: The results of this study demonstrated that pharmacists who work at hospitals had a higher awareness of practicing system of reporting ADRs than that of community pharmacists. Increasing awareness among community pharmacists regarding the pharmacovigilance and ADR reporting systems is highly recommended in the Kingdom of Saudi Arabia.

}, keywords = {Adverse drug reactions, Community, Hospital, Pharmacist, Pharmacovigilance, Practice, Saudi Arabia}, doi = {10.5530/ijpcs.2019.8.15}, author = {Fatima Fouad Al Doughan and Yousef Ahmed Alomi and Mais Hasan Iflaifel} } @article {233, title = {The Physician Order for Standardized Concentration of Adult{\textquoteright}s Electrolyte Replacement Therapy: New Initiative in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {December 2019}, pages = {208-210}, type = {Review Article}, chapter = {208}, abstract = {

The electrolyte replacement therapy consternation considered one of the high alert drugs. Most of the medication safety organizations have established preventive guidelines for the prescription of electrolyte therapy. The General Administration of Pharmaceutical Care at the Ministry of Health in the Kingdom of Saudi Arabia also has established guidelines for the preparation and administration of electrolyte replacement for adult patients. This new initiative is regarding the standardized concentration of electrolyte preparation and administration for adult patients. The electrolyte therapy may be prescribed via a physician order form, which may be easily converted as computerized physician order entry. This from is designed to prevent all electrolyte-related errors and improve patient outcomes. This project is a new tool implemented for electrolyte safety at the Ministry of Health hospitals in the Kingdom of Saudi Arabia.

}, keywords = {Adult, Electrolyte, Ministry of Health, Physician order, Saudi Arabia, Standardized Concentration}, doi = {10.5530/ijpcs.2019.8.46}, author = {Yousef Ahmed Alomi and Manal Mansour Al Nemari and Fatimah Al-Doughan and Yasir Ahmed Ibrahim and Hussam Saad Almalki and Nahedh Rashed Alotaibi and Mona Mustafa Jadkarim} } @article {110, title = {Effect of Kungiliya Vennai and Kalchunna Thailam on Excision Wound Healing in Albino Wistar Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {4}, year = {2015}, month = {Sept 2015}, pages = {52-57}, type = {Original Article}, chapter = {52}, abstract = {

Background: Kungiliya vennai and Kalchunna thailam are the two indigenous herbal formulation being used for healing of wounds in siddha medicine. Objectives: The objective of our study was to evaluate the wound healing property of topical application of kungiliya vennai (KV) and kalchunna thailam (KT) on excision wound in Sprague Dawley rats. Methods: Four groups of eight Sprague dawley female rats in each group were used for the study. Under anesthesia, excision wound of 300mm2 size was created using scissors. Group 1 served as control with no drugs applied. Group 2, 3 and 4 were applied with mupirocin, KV and KT respectively daily until wound was completely healed. Parameters observed were \% wound contraction rate and epithelialization period. Biopsy of wound for histology was taken on day 12 as well as the healed wound was taken after the wound was healed. Results were analyzed by one-way analysis of variance (ANOVA) followed by Tukey{\textquoteright}s test by keeping p\<0.05 as statistically significant. Results: Kalchunna thailam has increased wound contraction rate only during initial days, but not statistically significant. Kungiliya vennai treatment has increased vascularity with presence of tissue eosinophils when compared to control rats. There was a regeneration of adnexal skin structures in the Kungiliya vennai treated rats, which is not seen in other groups. The epithelialization period was significantly (p\<0.001) hastened in Group 3 (15.83 days) and 4 (15.17 days) compared to control group (21.33 days). Conclusion: The topical application of kungiliya vennai and kalchunna thailam promoted wound healing in rats. Kungiliya vennai has the additional property of regenerating adnexal structures such as hair follicles, sweat glands and sebaceous glands.

}, keywords = {Calcium, Kungiliya Vennai, Shorea Robusta, Siddha Medicine, Wound}, doi = {10.5530/ijpcs.4.3.4}, author = {Vishal Bhat and Arul Amuthan and Barizah Binti Mohamed Rosli and Nur Amirah Binti Khairuddin and Fatin Shahira Binti Md. Isa} } @article {165, title = {Pharmacoutilization and Costs of Nucleoside and Nucleotide Analog Inhibitors for Hepatitis B Treatment in the Vesuvian Area of South Italy}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {2}, year = {2013}, month = {June 2013}, pages = {55-57}, type = {Short Communication}, chapter = {55}, abstract = {

Hepatitis B virus (HBV) infection is an important sanitary problem due to its worldwide distribution and high social im-pact; severe complications of chronic hepatitis induced by HBV are cirrhosis and hepatocellular carcinoma (HCC). We conducted a survey with the aim i) to show the updated prevalence of the disease and ii) to evaluate the economic impact of treatment with oral agents (nucleoside and nucleotide analog inhibitors) in a region of the South Italy com-prising 1.012.304 inhabitants. Between January and December 2012, 778 patients with hepatitis B (prevalence: 0.08\%) were treated. The total pharmaceutical cost was {\texteuro} 2.082.926 (3\% of the total sanitary expense). Oral drugs against HVB have a moderate impact on the pharmaceutical spending. The major economic impact associated with HBV infection is primarily represented by the later development of cirrhosis and HCC.

}, keywords = {Hepatitis B, Pharmaceutical spending, Pharmacoutilization, Prevalence}, author = {Maurizio Capuozzo and Alessandro Ottaiano and Eduardo Nava and Stefania Cascone and Claudia Cinque and Adriano Vercellone and Rosario Vincenzo Iaffaioli} }