@article {115, title = {Evaluation of Hepatoprotective Activity of Aqueous Extract of Andrographis paniculata in Wistar Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {5}, year = {2016}, month = {December 2016}, pages = {113-11}, type = {Research Article}, chapter = {113}, abstract = {

Background: The objective of the current study was to evaluate the hepatoprotective activity of the aqueous extract of Andrographis paniculata in wistar rats. Materials and Methods: The animals were divided into six groups with six rats in each group. First group was taken as control, and received 0.9\% normal saline 10 ml/kg body weight orally. Second group was taken as CCl4 control group and treated with normal saline (10 ml/ kg, p.o.) and CCl4: olive oil (1:1, 2 ml/ kg, i.p. on 2, 5 and 8th day) daily for 20 day. The third group rats was treated with Liv 52- 100 mg/kg orally and CCl4: olive oil (1:1, 2 ml/ kg, i.p. on 2, 5 and 8th day) for 20 days .The fourth and fifth groups were taken as test groups and they received crude extract of Andrographis paniculata orally once daily for 20 days at the dosage of 250 and 500 mg/kg respectively. CCl4: olive oil was given i.p on 2, 5 and 8th day. On the 21st day, blood samples were collected by cardiac puncture method. The blood samples were used to estimate biochemical parameters like serum SGOT,SGPT, ALT, bilirubin and cholisterol and the liver was preserved for histopathological examination. Results: It was found that the Andrographis paniculata exhibited moderate protective effect by lowering the serum levels of SGOT,SGPT,ALT, bilirubin and cholisterol (P\<0.001). Histology of liver section of animal treated with the extracts showed the hepatic cell regeneration. Conclusion: Andrographis paniculata has dose dependant hepatoprotective activity.

}, keywords = {Andrographis paniculata, Carbon Tetrachloride, Hepatoprotective Activity, Herbals, Liver disease}, doi = {10.5530/ijpcs.5.4.4}, author = {Naveen Alasyam and Venkatanarayana Narapogu and Premendran John and Shaik Ubedulla and Naveen Pokala} } @article {111, title = {Short-term Toxicity Profile of Ethanol Extract of Solanum erianthum Leaf in Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {5}, year = {2016}, month = {December 2016}, pages = {103-108}, type = {Original Article}, chapter = {103}, abstract = {

Introduction: Solanum erianthum is medicinal plant used by folklore all over the world. There is no studies conducted on the toxicological effect of the plant. The present study aims to evaluate the toxicological effect of methanol extract of the leaf of the plant. Methods: The Solanum erianthum leaf was evaluated for toxic effects in Sprague Dawley rats. The extract was given in three doses (125,250,500 mg/kg BW of rats) for 14 days and the effect of the extract on the behaviour and normal physiology was assessed. Results: There was no mortality caused in any of the dosage groups. It was observed that the extract not has affected the normal behaviour and caused no deleterious effect on normal physiology, at all the doses given. Extract has no effect on pattern of weight gain and was comparable to normal control group. Serum biochemical parameters also were not altered and were comparable to normal control group. Conclusion: The results and observations of study it can be proposed that the extract has no mortality and is completely non toxic to the animal system.

}, keywords = {14 days repeated-dose toxicity profile, Hepatic enzymes, Histopathology, Safety profile, Solanum erianthum}, doi = {10.5530/ijpcs.5.4.2}, author = {Ramya URS and Lakshmidevi N} } @article {173, title = {Knowledge, Attitude and Practice of Adverse Drug Reaction Reporting Among Doctors in a Tertiary Health Care Centre in South India}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {2}, year = {2013}, month = {September 2013}, pages = {82-88}, type = {Research Article}, chapter = {82}, abstract = {

Background: A fundamental determinant to medical drug safety surveillance is voluntary adverse drug reaction [ADR] reporting ; but there exists substantial under-reporting which is the main drawback of the system. The objective of the study was to evaluate the knowledge, attitude and practice of ADR reporting among doctors in a tertiary health care center. Materials and Methods: A cross sectional questionnaire based study was conducted on doctors in a tertiary health care center. Participants were selected randomly and those not willing to participate were excluded from the study. Collected data was assessed by frequency, percentage, mean and standard deviation. Statistical analysis was performed by using SPSS version 13.0. Results: 75\% (45) of respondents were aware of the existence of ADR reporting system in India; on the contrary only (11.7\%) of respondents were aware of regional center for ADR reporting. All respondents (100\%) felt that seriousness of the ADR event, unusual reaction (95\%), reaction to new drug (98.33\%), and the certainty of ADR reaction (91.66\%) would encourage them to report an ADR event. However, only 15 out of 60 respondents (25\%) have reported ADRs. Conclusion: Though the level of knowledge about ADR reporting and the attitude towards ADR reporting were adequate, our study has shown that the actual practice of ADR reporting is unsatisfactory. This indicates that there is a need to create an awareness of the importance of ADR reporting through continuous medical education and training of ADR reporting among doctors.

}, keywords = {ADR reporting, Adverse drug reaction}, author = {Tanya Mary Thomas and Padmaja Udaykumar and Scandashree K} }