@article {97, title = {Pharmacogenomics of Metformin- A Way to Personalised Medicine}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {5}, year = {2016}, month = {June 2016}, pages = {55-61}, type = {Review Article }, chapter = {55}, abstract = {

Diabetes is fast gaining the status of a potential epidemic in India with more than 62 million diabetic individuals currently diagnosed with the disease. There are atleast 10 different drug classes for the treatment of Type 2 diabetes mellitus (T2DM) but metformin is recommended as the initial medication for treatment of T2DM. Inter-individual variability in response and few clinical or biomarker predictors of response reduces its optimal use. Personalized medicine promises a path for individually optimized treatment, but realizing this promise will require a more comprehensive characterization of disease and drug response. As per American Medical Association, pharmacogenomics is the study of genetic variations that influence individual response to drugs. Knowing whether a patient carries any of these genetic variations can help prescribers individualize drug therapy, decrease the chance for adverse drug events, and increase the effectiveness of drugs. There are variety of genes controlling metformin transport in the body, for eg- SLC22A1, SLC22A2, SLC22A3, SLC22A4 etc. The purpose of this review article is to explain in brief pharmacogenomics of metformin and its application and practical hurdles in its translation.

}, keywords = {Diabetes Mellitus, Metformin, Personalised medicine, Pharmacogenomics, SLC2A4}, doi = {10.5530/ijpcs.5.2.4}, author = {Monali Pradeep Vakharia and Vijay Ramakrishna Zad and Nishikant Nandlal Mankar and Pratik Pradeep Wadivkar and Kalpana Unind Shah} } @article {178, title = {Acute and Chronic Toxicity Study of Ethyl Acetate Fraction of Caralluma tuberculata in Mice}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {2}, year = {2013}, month = {December 2013}, pages = {99-104}, type = {Research Article}, chapter = {99}, abstract = {

Background: Caralluma tuberculata (Asclepiadaceae), a succulent perennial herb used as vegetable is reported to treat the diabetes and rheumatism. In the present study the safety profile of Caralluma tuberculata (CT) was evaluated by gross behavioral, acute and chronic toxicity study of ethyl acetate fraction of ethanolic extract of CT in Swiss albino mice. Materials and Methods: For acute toxicity study, mice were divided into seven groups. Normal saline was given by intraperitoneal route to control group and to other six groups, different doses of extract i.e. 0.5, 1, 1.5, 2, 2.5 and 3 g/kg body weight was given to the mice intraperitoneally. In chronic toxicity study, 100mg/kg body weight was given intraperitoneally route for three months. In acute toxicity mortality rate was determined, while in chronic toxicity changes in body and organ weight, biochemical, hematological parameters in both male and female mice, and spermatotoxic effects in male mice were measured by using standard procedures. Statistical analysis was carried out by student t-test. Results: Acute toxicity showed that the ethyl acetate fraction was safe up to 3g/kg body weight in mice. In gross behavioral study some signs of passivity and decreased spontaneous activity were observed. No mortality was observed in chronic toxicity study. No detectable alterations were found on weight, vital body organs, biochemical, and hematological parameters; no spermatotoxic effects in treated mice were observed when compared to vehicle control group after three months of chronic treatment. Conclusion: The results of present study therefore indicated that ethyl acetate fraction of ethanolic extract of Caralluma tuberculata was safe in test animals demonstrating no noticeable toxicity.

}, keywords = {Caralluma tuberculata, Ethyl acetate fraction, Gross behavioral, Spermatotoxic}, author = {Qazi Najam-us-Saqib and Rahila Qayyum and Abdul Waheed} } @article {159, title = {Hepatoprotective Activity of Plectranthus Amnoinicus Against Paracetamol Induced Hepatotoxicity in Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {1}, year = {2012}, month = {June 2012}, pages = {32-38}, type = {Research Article}, chapter = {32}, abstract = {

Background:Plectranthus amboinicus, belonging to the genus Plectranthus, is widely used for medicinal purposes. Its leaves have been used traditionally as a heatoprotective.\ Objectives:\ The present study was aimed at evaluating the heapatotective activity of ethanolic extract of Plectranthus amboinicus against paracetamol induced heapatotoxicity in rats.\ Materials and Methos:\ Sic groups wistar rats were used in the study. The two control groups received gum acacia and paracetamol orally respectively. The three test groups were treated orally with paracetamol followed by 300, 600 and 900 mg/kg of ethanolic extract of pletranthus amboinicus respectively. The sixth group (standard hepatoprotective) received paracetamol followed by N-aceltylcysteine 100 mg/kg orally. The hepatoprotective activity was evaluated by estimating serum alanine aminotransferase, asparatate aminotransferase, alkaline phosphatase, tissue malondialdehyde levels and by histopathological analysis of the liver tissue. Results were analysed by one-way ANOVA followed by Dunnett{\textquoteright}s multiple comparison test.\ Results:\ Plectranthus amboinicus in doses of 600 mg/kg and 900 mg/kg siginificantly (p\<0.05) altered paracetamol induced changes in the serum and tissue enzyme levels to near normal values. It also improved the liver histopathology profile.\ Conclusion:\ The results of the study indicate that the ethanolic extract of Plectranthus amboinicus, possesses hepathoprotective activity against paracetamol induced hepatotoxicity in rats.

}, keywords = {Hepatoprotective, N-acetylcysteine, Paracetamol, Plectranthus Amboinicus}, author = {Smita Shenoy and Hemanth Kumar and Thashma and Veena Nayak and Krishnananda Prabhu and Priya Pai and Indu Warrier and Somayaji and Venu Madhav and KL Bairy and Anoop Kishore} }