@article {125, title = {Chelation of Lanthanum (La3+) by Various Thiols - an in vitro Study}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {3}, year = {2014}, month = {June 2014}, pages = {34-38}, type = {Short Communication}, chapter = {34}, abstract = {

In the present study the interaction of various thiols (L-glutathione, L-cysteine, N-acetyl cysteine and D-penicillamine) with LaCl3 was studied in vitro by modified Ellman{\textquoteright}s method. Experiments carried out at various concentrations inferred gradual decrease in thiol concentration with the increase in La3+ concentration in aqueous solutions. Maximum interac-tion between thiols and La3+ was observed at pH 7.5 and 35{\textdegree}C as indicated by the lowest values of residual thiol con-centration. The order of reactivity was DPA\>GSH\>NAC\>Cys, where reactivity increased with increasing pKa of their thiol group. The possible products of reaction are proposed to be La(RS)3 complex or oxidized form with disulfide bond (RSSR).

}, keywords = {Chelation, Ellman{\textquoteright}s modified method, Lanthanum, Thiols}, author = {Muhammad Yaqoob and Muhammad Farid Khan and Muhammad Tausif Chaudhry and Izhar Ahmad Shaikh} } @article {160, title = {Antidiabetic and Hepatoprotective Activities of Tamarindus indica Fruit Pulp in Alloxan Induced Diabetic Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {2}, year = {2013}, month = {June 2013}, pages = {33-40}, type = {Research Article}, chapter = {33}, abstract = {

Background: Tamarindus indica belongs to family Caesalpiniaceae. Fruit pulp of Tamarindus indica is believed to have antidiabetic, hepatoprotective and many other medicinal properties. The objective of this study was to investigate antidiabetic, hypolipidemic and hepatoprotective activity of ethanolic extract of Tamarindus indica fruit pulp in alloxan induced diabetic rats. Materials and Methods: Animals were divided into 5 groups (n = 6). Normal and diabetic control groups received normal saline and alloxan (150 mg/kg body weight intraperitoneally) respectively. Animals were made diabetic by injection of single dose of alloxan in three test groups and after that they were treated with ethanolic extract of fruit pulp of Tamarindus indica 300 and 500 mg/kg/body weight orally and metformin 150 mg/kg body weight orally respectively for 14 days. Antidiabetic activity was estimated by measuring serum glucose and lipid profile; and hepatoprotective activity was measured by estimating serum liver enzyme levels and histopathological changes in liver tissues. Results were analyzed by One way ANOVA followed by Scheffe multiple comparison tests (p\<0.01). Results: The two dose levels of Tamarindus indica significantly altered alloxan induced changes in serum glucose, lipid profile and serum enzyme levels. But in liver histopathology, higher dose (500 mg/kg) of plant showed complete regeneration whereas lower dose (300 mg/kg) showed only partial improvement in liver histopathology profile. Conclusion: Present study revealed that Tamarindus indica possesses antidiabetic and hepatoprotective activity in alloxan induced diabetic rats.

}, keywords = {Alloxan, Antidiabetic, Hepatoprotection, Tamarindus indica}, author = {Narendar Koyagura and V. Hemanth kumar and M.G Jamadar and Shobha V Huilgol and Nagendra Nayak and Saeed M Yendigeri and Mohd Shamsuddin} }