@article {131, title = {Gastroprotective Activity of Asystasia gangetica Stem Aqueous Extract Against Pylorus Ligated Gastric Ulcer in Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {3}, year = {2014}, month = {September 2014}, pages = {53-60}, type = {Research Article}, chapter = {53}, abstract = {

Background: Asystasia gangetica, a medicinal plant commonly known as Maithal Kadi available in Udupi district in India. It is used as a fresh juice to treat gastric ulcers, rheumatism, inflammation, swelling by the folklore practitioners. The present studies were aimed to investigate the antiulcer activity of aqueous extract of Asystasia gangetica stem to provide scientific validation for its folklore use. Materials and Methods: Healthy Wistar albino rats were divided into three different groups of six rats each. The rats were pre-treated with group specific drugs. Group I assigned as control, group II received the standard drug omepra-zole 20 mg/kg, group III received aqueous extract of stem of the plant Asystasia gangetica 400 mg/kg once daily for seven consecutive days. On seventh day, one hour after drug administration, the gastric ulcer was induced by ligation of the pyloric part of the rat{\textquoteright}s stomach. This was followed by the macroscopic examination of the stomach, quantifica-tion of gastric juice, total and free acidity, peptic activity and histological examination of stomach tissue were performed. The test extract were subjected for preliminary phytochemical analysis as per standard methodology. Results: The test drug treated group showed that there is a significant reduction in the total acidity and marked reduction in ulcer index, the volume of gastric juice and the effect was comparable with that of omeprazole. Histologi-cal examination revealed a normal cytoarchitecture with reduced gastric lesions in group III compared to group I. Conclusion: The present finding suggests that Asystasia gangetica promotes ulcer protection as ascertained by the comparative decreases in total acidity, gastric lesions and peptic activity.

}, keywords = {Asystasia gangetica, Gastro protection, Leukocyte, Omeprazole, Pylorus ligation, Ulcer index}, author = {Lalith Kumar and Ravi M and Shridhara Bairy and Chaithra Hebbar and Ravi Shankar B} } @article {180, title = {Experimental Evaluation of Analgesic and Anti-inflammatory Potential of Leaves of Antidesma Menasu on Wistar Albino Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {2}, year = {2013}, month = {December 2013}, pages = {105-112}, type = {Research Article}, chapter = {105}, abstract = {

Background: Antidesma menasu is a folk plant of Euphorbiacae occurring in and around Udupi district in India. It is effectively used in folklore medicine for the management of arthritis, inflammatory bowel disorder and low backache. The present study aimed to evaluate the anti-inflammatory and analgesic activity of the plant in Wistar albino rats. Aqueous extract of leaves of A. menasu were evaluated for possible analgesic and anti-inflammatory activities in Wistar albino rats. Materials and Methods:Eddy{\textquoteright}s hot plate test and radiant heat test were used for investigation of analgesic effect. Effect of extract on the acute inflammation was investigated on Carrageenan induced paw oedema, and chronic inflammation was investigated on cotton pellet induced granuloma tissue formation test. The test extract was subjected for preliminary phytochemical examination as per standard methodology. Results: The test drug found to inhibit the carrageenan induced paw oedema significantly (p ˂ 0.05) and there was moderate increase in the latency period in the analgesic test. The results suggest that the test group has high signifi-cant anti-inflammatory potential and there is moderate analgesic activity. The histopathological examination of adrenal cortex, spleen and thymus showed a normal cytoarchitecture comparable with that of normal control group. The preliminary phytochemical screening of the aqueous extract of the plant A. menasu revealed the presence of flovanoids, saponins, steroids and phenols. Conclusion: The data obtained supports the traditional folklore therapeutic claim about its anti-inflammatory and anal-gesic activity. Further scientific investigation is required to establish its analgesic and anti-inflammatory property in other experimental models and clinical settings.

}, keywords = {Antidesma menasu, Arthritis, Carrageenan, Chronic inflammation, Flavonoids}, author = {Arun Prabhakar Sithara and Ravi M and Suma Mallya and Sudhakara and Sridhar Bairy and Srikanth P and Ravishankar} }