@article {78, title = {Comparative Study of Hypolidemic effects of Ethanolic extract of Rhizomes of Curcuma longa (turmeric) Versus Pioglitazone in Alloxan induced Diabetic Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {5}, year = {2016}, month = {March 2016}, pages = {5-11}, type = {Research Article}, chapter = {5}, abstract = {

Background: Rhizomes of Curcuma Longa belonging to the genus, Curcuma is widely used for medicinal purpose. Its ethanolic extract has been used traditionally as a hypolipidemic. Objectives: The present study was undertaken to evaluate the hypolipidemic effects of ethanolic extract of Rhizomes of Curcuma longa in Alloxan induced diabetic rats with high fat diet and compared with of Pioglitazone, which has anti-diabetic and action. Materials and method: Alloxan monohydrate was used to induce diabetes mellitus in albino rats in the dose of 120 mg/kg Intraperitonelly and hyperlipidemia was induced by feeding animals with high fat diet orally. The body weights of the rats in every group was recorded weekly. Six groups of 6 animals in each received normal saline for normal control, normal saline for diabetic control, turmeric extract (TE) 300 mg/kg/day for euglycemic rat, Diabetic rat with high fat diet 10 mg/kg/day (turmeric extract 300 mg/kg/day), diabetic rat with high fat diet 10 ml/kg/day (turmeric extract 500 mg/kg/day), Diabetic rats with High fat diet 10 ml/kg/day (pioglitazone respectively for 4 weeks). After overnight fasting, 2 ml of blood was collected in from orbital sinuses of all animals. Various biochemical parameters were estimated like blood sugar and lipid profile. The data was analyzed statistically using student{\textquoteright}s paired and unpaired t-test. Results: Turmeric extract significantly raised HDL levels both in healthy and diabetic rats. TE (500 mg/kg) is more efficient as compared to 300 mg/kg dose, as TE (500 mg/kg) has also reduced VLDL, LDL levels in Group V which was statistically highly significant (p\<0.001). Conclusion: Present study revealed that the turmeric has hypolipidemic action and can be safely used in the treatment of mild to moderate cases of hyperlipidemia.

}, keywords = {Alloxan, Curcuma Longa, Diabetic Rats, Hypolipidemic, Turmeric}, doi = {10.5530/ijpcs.5.1.2}, author = {Jeevangi Santoshkumar and Deepak D. Mariguddi and S. Manjunath} } @article {170, title = {Wound Healing Property of Topical Application of Ethanolic Extract of Michelia champaca Flowers in Diabetic Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {2}, year = {2013}, month = {September 2013}, pages = {67-74}, type = {Research Article}, chapter = {67}, abstract = {

Background: The plant Michelia champaca (MC) is widely used in the treatment of inflammation, constipation, dysmenorrhea, ulcers, wounds, fever and cough. The objective of the study was to evaluate the wound healing property of topical application of ethanolic extract of MC flowers in streptozotocin induced diabetes in rats. Materials and Methods: Wound healing activity was assessed by incision and excision wound models. Five groups of 10 rats each were used for each of incision and excision wound model. Group I rats, non-diabetic control and group II rats diabetic control, were anointed topically with ointment base. The diabetic rats in test groups III, IV and V were anointed with topical MC extract ointment of 2.5\%, 5\% and 10\% respectively. Parameters observed were breaking strength of incision wound and wound contraction, epithelialization, hydroxyproline content of excision wound respec-tively. Results were analyzed by one-way analysis of variance (ANOVA), followed by Tukey{\textquoteright}s post hoc test. Results: Breaking strength, rate of wound contraction and hydroxyproline content were significantly increased and period of epithelialization was significantly reduced in Group IV and V rats respectively. Conclusion: The topical application of ethanolic extract of Michelia champaca promotes wound healing in diabetic rats. Hence further study in humans is suggested.

}, keywords = {Diabetic Rats, Excision wound, Hydroxyproline, Incision wound}, author = {Amoolya Gowda and Venkatesh Shanbhag and Smita Shenoy and Eesha Rao Bangalore} }