@article {115, title = {Evaluation of Hepatoprotective Activity of Aqueous Extract of Andrographis paniculata in Wistar Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {5}, year = {2016}, month = {December 2016}, pages = {113-11}, type = {Research Article}, chapter = {113}, abstract = {

Background: The objective of the current study was to evaluate the hepatoprotective activity of the aqueous extract of Andrographis paniculata in wistar rats. Materials and Methods: The animals were divided into six groups with six rats in each group. First group was taken as control, and received 0.9\% normal saline 10 ml/kg body weight orally. Second group was taken as CCl4 control group and treated with normal saline (10 ml/ kg, p.o.) and CCl4: olive oil (1:1, 2 ml/ kg, i.p. on 2, 5 and 8th day) daily for 20 day. The third group rats was treated with Liv 52- 100 mg/kg orally and CCl4: olive oil (1:1, 2 ml/ kg, i.p. on 2, 5 and 8th day) for 20 days .The fourth and fifth groups were taken as test groups and they received crude extract of Andrographis paniculata orally once daily for 20 days at the dosage of 250 and 500 mg/kg respectively. CCl4: olive oil was given i.p on 2, 5 and 8th day. On the 21st day, blood samples were collected by cardiac puncture method. The blood samples were used to estimate biochemical parameters like serum SGOT,SGPT, ALT, bilirubin and cholisterol and the liver was preserved for histopathological examination. Results: It was found that the Andrographis paniculata exhibited moderate protective effect by lowering the serum levels of SGOT,SGPT,ALT, bilirubin and cholisterol (P\<0.001). Histology of liver section of animal treated with the extracts showed the hepatic cell regeneration. Conclusion: Andrographis paniculata has dose dependant hepatoprotective activity.

}, keywords = {Andrographis paniculata, Carbon Tetrachloride, Hepatoprotective Activity, Herbals, Liver disease}, doi = {10.5530/ijpcs.5.4.4}, author = {Naveen Alasyam and Venkatanarayana Narapogu and Premendran John and Shaik Ubedulla and Naveen Pokala} } @article {90, title = {Pediatric Liver Diseases and its Management by Herbals: A Traditional Siddha Medicine Treatise}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {5}, year = {2016}, month = {March 2016}, pages = {32-40}, type = {Review Article}, chapter = {32}, abstract = {

Siddha medicine is one of the oldest (5000 years old, pre vedic period) well-documented Indian traditional medicines, compared to Ayurveda, Unani, and traditional Chinese medicine, by way of keen observation and experimentation. It mentions 108 diseases that occur in childhood, which are further classified and described into various subtypes based on the clinical features and different stages of a particular disease. The objective of this review was to collect literature details on pediatric liver diseases and its management as per Siddha medicine. We have referred all the published Siddha books related to the pediatric practice. There were 37 Siddha literature deals pediatric diseases and they use the term kaamaalai or chenkamaari to describe the liver diseases. Most of the literature classifies liver disease into 3 types, but few texts describe 5-6 subtypes. Thus, a total of 9 subtypes of liver diseases in pediatric age group have been described in Siddha literature with a list of herbals to be used for each type. Mostly, the drug therapy is polyhedral formulations of internal and/or external application. A total of 113 herbals, 6 animal products (including black chicken liver, dairy products, donkey{\textquoteright}s dung, honey) and 7 mineral based products (including iron, rock salt) were listed as potential agents to treat liver diseases. The safety and efficacy of all the above mentioned herbal/mineral products have not been fully explored in children, but may be a great potential for clinical development.

}, keywords = {Agastyar, Ayurveda, Herbals for Children, Liver disease, Traditional Medicine}, doi = {10.5530/ijpcs.5.1.6}, author = {G Senthilvel and Arul Amuthan and Shiny Jasphin} }