@article {106, title = {Ulcer Protective Action is Improved by Washing Fresh Aloe vera Gel: A Comparative Study with Unwashed Gel in Indomethacin and Ethanol Induced Ulcers in Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {5}, year = {2016}, month = {September 2016}, pages = {83-89}, type = {Original Article}, chapter = {83}, abstract = {

Introduction: The Aloe vera and its components has been widely suggested for its ulcer protective action. Traditional Indian Siddha medical literature claims that washing the fresh Aloe vera gel (FAVG) has improved ulcer protective action due to the removal of bitter yellow latex. In this study, we compared the ulcer protective effect of unwashed as well as washed fresh Aloe vera gel in rats. Methods: We prepared washed and unwashed FAVG. Albino rats were fed with normal saline, ranitidine suspension, washed and unwashed FAVG for 8 days. Drugs have been tested in two ulcer models, in which indomethacin (20mg/kg) and ethanol (80\%) were used for the induction of ulcer after animals were fasted for 24 hours. The animals were sacrificed and stomach was cut open to calculate mean ulcer index and a section was sent for histopathological examination. One Way ANOVA was done for analysis. Results: In indomethacin induced ulcer model, the mean ulcer index in control, ranitidine, washed and unwashed FAVG treatment groups were 7.67 {\textpm} 1.51, 1.92 {\textpm} 1.12, 2.17 {\textpm} 1.16 and 4.0 {\textpm} 1.09 respectively. The percentage of ulcer protection in washed FAVG treatment (71.71\%) is comparable with ranitidine treatment (74.97\%), whereas the unwashed FAVG showed only 47.84\% ulcer protection. In ethanol induced ulcer model, the mean ulcer index in control, ranitidine, washed and unwashed FAVG treatment groups were 7.83 {\textpm} 1.51, 1.83 {\textpm} 0.82, 2.33 {\textpm}1.37 and 4.17 {\textpm} 1.47 respectively. The percentage of ulcer protection in washed FAVG treatment (70.24\%) is comparable with ranitidine treatment (76.63\%), whereas the unwashed FAVG showed only 46.74\% ulcer protection. In both the above ulcer models, washing the FAVG showed statistically significant (p\<0.05) reduction in ulcer index and improved ulcer protection. Conclusions: Washed fresh Aloe vera gel has shown higher ulcer protective activity compared to unwashed gel.

}, keywords = {Aloe latex, Aloe vera gel, Ayurveda, Ethanol, Gastric Ulcer, Indomethacin, Siddha}, doi = {10.5530/ijpcs.5.3.4}, author = {Jyoti Tara Manandhar Shrestha and Roanak Shrestha and Maya Shrestha and Saurab Raj Joshi and Merina Rajbhandari} } @article {162, title = {Evaluation of Gastroprotective Role of Alpha-tocopherol in Indomethacin Induced Peptic Ulcer in Albino Rats}, journal = {nternational Journal of Pharmacology and Clinical Sciences}, volume = {1}, year = {2012}, month = {June 2012}, pages = {39-44}, type = {Research Article}, chapter = {39}, abstract = {

Background:\ Oxidative free radicals induce gastric injury in animal models of peptic ulcer. Hence antioxidants may provide gastroprotection.\ Objectives:\ The present study was undertaken to evaluate the gastroprotective role of antioxidant alpha-tocopherol in indomethacin induced gastric ulceration in albino rats.\ Materials and methods:\ Animals were diveded into 3 groups (n=6) group 1 (control which received distilled water), group11 (alpha-tocopherol 12.5 mg/kg) and group 111 ( omeprazole 3.6 mg/kg). Each group received the corresponding 4 hours, animals were sacrificed and their stomachs were studied for ulcerationm, adherent mucin content, and ulcer index was calculated. The results of alpha-tocopherol were compared with those of control and omeprazole treated groups and data was analyzed manually using Student t test. A p Value of \< 0.05 was considered as satistically significant.\ Results:\ Alpha-tocopherol administrative reduce ulceration and ulcer index compared to control group (t cal5.2\>tab 2.23 at 5\% level of significance, p\<0.05). Omeprazole treatment also reduced ulcer index and ulceration in comparison to control group (tcal 6.2\>ttab 3.16 at 1\% level of significance, p\<0.01). Thus results of test drug were similar to omeprazole treated group.\ Conclusion:\ Alpha-tocopherol treatment provides gastroprotection in indomethacin induced gastric ulceration.

}, keywords = {Alpha-tocopherol, Antioxidant, Gastroprotection, Indomethacin}, author = {Shobha V Huligol and V. Hemanth kumar and K. Narendar} }