@article {245, title = {Ophthalmic medication Therapeutic Interchanges: A Narrative Reviews}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {9}, year = {2020}, month = {November 2020}, pages = {120-123}, type = {Review Article}, chapter = {120}, abstract = {

Objective: To review the ophthalmic medication therapeutic interchanges therapy. Methods: It is an extensive search, or fifty databases comprised the following through the Saudi Digital Library (SDL) searching engine. It included the various types of studies (meta-analysis, randomized controlled studies and observational studies) in the English language with human study only for the update May 2017. The search in terms of therapeutic interchange, medication, therapy and type of disease or medication base on therapeutics class of Anti-psychiatric. The medication list and switch from one drug to another based on the literature found the search that has included comparative safety, efficacy and cost of the type of medication for each disease and national or international evidence-based guidelines. Results: The total number of studies after an extensive search with a specific term search was 487 studies. Of those, there were 107 duplicated studies, and 380 studies included for future evaluation. After evaluation, there were 5 studies had been found discussed the ophthalmic medications. Conclusion: Ophthalmic medications therapeutic interchange is rare in finding studies about the topic. It recommended starting generic interchange or evidence-based ophthalmic therapeutic international guidelines.

}, keywords = {Eye, Literature, Ophthalmic, Review, Therapeutic interchanges}, doi = {10.5530/ijpcs.2020.9.24}, author = {Yousef Ahmed Alomi and Faiz Abdullah Bahadig} } @article {119, title = {An Open Label, Randomized, Comparative Study of Antiscabietic Drugs Permethrin, Gamma Benzene Hexachloride and Ivermectin in Patients of Uncomplicated Scabies}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {3}, year = {2014}, month = {June 2014}, pages = {15-21}, type = {Research Article}, chapter = {15}, abstract = {

Background: To determine efficacy and cost effectiveness of antiscabietic drugs (permethrin, gamma benzene hexa-chloride and ivermectin) in patients of uncomplicated scabies. Materials and Methods: This was a prospective, randomized clinical study conducted in 210 diagnosed patients of scabies (\>12years of age) from January 2011 to October 2011.They were randomly allocated into one of the three groups. Group A received topical permethrin (5\% cream), Group B received topical gamma benzene hexachloride (1\% lotion) and Group C received oral ivermectin (tab 200mcg/kg). All the three groups received treatment two times- at the time of first visit and one week later. The patients were followed up at the end of first and third week. At each visit, cure rate was assessed by clinical and itching grading score and compared to determine the efficacy. Cost effectiveness was compared on basis of cost in INR to treat one case successfully. Results: Cure rate at the end of first week was 83.87\% in Group A, 78.18\% in Group B and 55.17\% in Group C while cure rate in the three treatment groups at the end of third week was 93.55\% in Group A, 80.00\% in Group B and 98.28\% in Group C. Thus at the end of first week Group A showed better cure rate while at the end of third week Group C was equally efficacious to Group A. The cost (INR) to treat one patient was 69.19 for permethrin, 37.50 for gamma benzene hexachloride and 24.42 for ivermectin. Conclusion: A single application of permethrin is superior to both ivermectin and gamma benzene hexachloride while ivermectin in two dose regimen is equally efficacious to permethrin and more cost effective than the other two conven-tional antiscabietic drugs. Oral ivermectin can be used as an alternative to permethrin.

}, keywords = {Antiscabietic, Gamma benzene hexachloride, Ivermectin, Permethrin}, author = {Maurya Meenakshi and Kaushik Sadhna and Srivastava Neeraj and Verma Deepak and Parihar Renu} }