02704nas a2200265 4500008004100000245014300041210006900184260001500253300001000268490000600278520194600284653001302230653001102243653002602254653001002280653001502290653001102305653001202316653001302328653001102341100000502352700000502357700001802362856005802380 2015 eng d00aPhysico-Chemical Evaluation of Pavalasilasathu Parpam, a Marine based Traditional Siddha Drug used in Leucoderma and Infectious Conditions0 aPhysicoChemical Evaluation of Pavalasilasathu Parpam a Marine ba cSept 2015 a44-470 v43 a

Background: Pavalasilasathu parpam (PSP) is one of the marine derived drugs used in Siddha Medicine for the treatment of leucoderma and respiratory infections. So far, no studies have been done on this drug. Objective: To prepare pavalasilasathu parpam as per the traditional Siddha literature and to evaluate its chemical changes during drug preparation processes. Materials and Methods: First, Suddhi (purification) process of pavalam (coral) and silasathu (selenite) were done by individually processed with Aloe vera juice and tender coconut water respectively. The chemical change in coral and selenite before and after the purification process was analyzed using Fourier transform infrared spectroscopy (FTIR) and inductively coupled plasma optical emission spectroscopy (ICP-OES). Then, coral and selenite were ground well together with Cissus quadrangularis juice for 12 hours and subjected to calcination process. The obtained whitish ash was called as PSP. The physico-chemical property of PSP was analyzed using ash values, FTIR, ICP-OES and Scanning Electron Microscope (SEM). Amount of heavy metal was quantified. Results: The procedure Suddhi reduced the amount of sodium, iron, calcium, phosphorous, sulfur and magnesium in coral and selenite. Particle size ranges between 30-80 μm. Heavy metals like mercury, lead, arsenic and cadmium were below detectable level. Amount of calcium, phosphorous and sulphur were 225 mg, 10 mg and 22 mg in 1 g of PSP. FTIR showed the peaks for the presence of six organic compounds. Conclusion: Pavalasilasathu parpam does not have heavy metals, but contains calcium, phosphorous and Sulphur with few organic phytochemicals derived from Cissus quadrangularis, which was used during the preparation process.

10aAyurveda10aBhasma10aCissus Quadrangularis10aCorel10aLeucoderma10aMarine10aPavalam10aSelenite10aSiddha1 a1 a1 aAmuthan, Arul uhttps://www.ijphs.org/article/2015/4/3/105530ijpcs432