02645nas a2200265 4500008004100000245009200041210006900133260001400202300001000216490000600226520186900232653001802101653001302119653001502132653002202147653001102169653002202180100002502202700002002227700001802247700001902265700002402284700002802308856004302336 2012 eng d00aAreca Catechu: Effect of Topical Ethanolic Extract on Burn Wound Healing in Albino Rats0 aAreca Catechu Effect of Topical Ethanolic Extract on Burn Wound  cSept 2012 a74-780 v13 a

Background: Areca nut (Areca catechu Linn.) is commonly used for skin ulcers in Indian traditional medicine. Areca nut oil is prepared and is applied topically for burn wound healing. However, scientific study has not been conducted so far. Hence, this study was aimed to evaluate burn wound healing activity of Areca catechu. Objective: To evaluate the burn wound healing property of Areca catechu kernel in normal as well as dexamethasone treated rats. Materials and Methods: Ethanolic extract of Areca catechu kernel was prepared and an ointment was made with 2% of this extract. Burn wound was induced by standard procedure. Rats with burn wound model received either vehicle, standard drug or test drug. Two other groups were injected with dexamethasone to delay the wound healing process. The dexamethasone treated groups received either vehicle or test drug topically. Wound contraction rate and period of epithelialization were measured. The collected data were subjected to statistical analysis. Results: The wound contraction rate was significantly increased in Areca catechu treated group in all the days compared to control. Period of epithelialization was faster in the drug treated group than control group. The dexamethasone treated group showed a significant delay in wound healing process when compared to control. Test drug showed a significant reversal in wound contraction rate and epithelialization period in dexamethasone suppressed burn wound healing model. Conclusion: This study has shown the wound healing property of Areca catechu. Further study is required to know the compounds responsible for its wound healing property and to understand the mechanism of action.

10aAreca Catechu10aAyurveda10aBurn Wound10aEpithelialization10aSiddha10aWound Contraction1 aVerma, Deepak, Kumar1 aBharat, Masuram1 aNayak, Deepak1 aShanbhag, Tara1 aShanbhag, Venkatesh1 aRajput, Ravindra, Singh uhttps://www.ijphs.org/article/2012/1/3