In-vitro Alpha-glucosidase Inhibitory Activity of Abraga Chendhooram, a Siddha Drug

R. Sathish; R. Madhavan; Hannah R. Vasanthi; Arul Amuthan

Abstract

International Journal of Pharmacology and Clinical Sciences,2012,1,3,79-81.

Published:Sep 2012

Type:Short Communication

Authors:

Author(s) affiliations:

R. Sathish¹, R. Madhavan², Hannah R. Vasanthi³, Arul Amuthan^4*

¹Department of Toxicology, Sri Sairam Siddha Medical College, Chennai, India

²Department of Toxicology, National Institute of Siddha, Chennai, India

³Herbal and Indian Medicine Research Laboratory, Department of Biochemistry, Sri Ramachandra University, India

⁴Department of Pharmacology, Melaka Manipal Medical College, Manipal University, India

Abstract:

The present study was carried out to evaluate alpha-glucosidase inhibitory activity of abraga chendhooram which is a Siddha drug being used to treat diabetes mellitus. The ingredient of abraga chendhooram includes biotite (K(Mg,Fe)3AlSi3O10(F,OH)2), Sesbania grandiflora, Calotropis gigantea and Momordica charantia. In-vitro alpha-glucosidase inhibitory assay was performed by standard procedure. Different concentrations of abraga chendhooram and miglitol (standard drug) were used. Abraga chendhooram exhibited a dose dependent alpha-glucosidase inhibitory activity, but it was less than standard drug. Further studies are warranted to look other possible mechanisms for its antidiabetic claim and to assess its safety

Keywords:Abraga, Ayurveda, Basma, Biotite, Diabetes Mellitus, Herbo-metallic, Mica