Objectives: This study aims to demonstrate the Research Policy of Pharmacy Investigational Medication as a new initiative in Saudi Arabia. Methods: This article is a narrative review of pharmacy research. Litterateur researched specific research policies and procedures in pharmacy practice using a variety of databases, including PubMed, Medline, and Google Scholar. The time period covered for the search is from the 1960s to October 2021. The terms used are in the English language and encompasses narrative reviews, systemic reviews, meta-analyses, and guidelines. The search term includes all hospital and community pharmacy-related services. Besides, there are national and international guidelines for conducting general research in hospital settings. The pharmacy research committee was formed and comprised numerous expert members, including clinical pharmacists, pharmacists specializing in drug information, and clinical research specialists. A member drafted the policy’s guidelines, which were then reviewed and corrected by another member. The research specialist made the third revision. The subject emphasizes Pharmacy Research’s policy on Investigational Medication. Results: The Pharmacy Research policy for Investigational Medication consisted of a number of components, including the administration of pharmacies, the procurement of investigational drugs, and the storage of investigational drugs. Additionally, the investigative drug prescription, the preparation of investigative drugs, the dispensing of investigative drugs, the administration of investigative drugs, and the monitoring of investigative drugs. There were a number of essential policy items, including the safety of investigational medications, the cost of investigational drugs, and the sponsors of investigational drug research. Conclusion: The Pharmacy Research policy for Investigational Medication is a new initiative as part of pharmacy practice research and development. Investigational Medication Pharmacy Research policy helps healthcare organizations improve patient safety and prevent drug-related morbidity and mortality. It is a component of Saudi Arabia’s pharmacy strategic plan for Vision 2030 and pharmacy reimbursement initiatives.